{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T05:20:16Z","timestamp":1717392016590},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T00:00:00Z","timestamp":1454457600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>The induction of a pan\u2010immunosuppressive state is a central feature of persistent viral infections. Over the past decade, multiple pathways have been identified that contribute to immune suppression. Recently, it was revealed that aberrant or sustained type 1 interferon (IFN\u2010I) production or signaling is a central contributor to immune suppression elicited during persistent viral infection. In this issue, Honke et\u00a0al. [<jats:italic>Eur. J. Immunol<\/jats:italic>. 2016. 46: 372\u2013380] identify that IFN\u2010I signaling promotes an immune suppressive state during persistent lymphocytic choriomeningitis virus infection by inhibiting enforced virus replication in CD169<jats:sup>+<\/jats:sup> macrophages. The authors demonstrate that mice infected with a persistent strain of lymphocytic choriomeningitis virus have blunted humoral immune responses to a superinfecting vesicular stomatitis virus infection. The absence of virus replication in CD169<jats:sup>+<\/jats:sup> macrophages was not due to antiviral CD8<jats:sup>+<\/jats:sup> T cell\u2010mediated killing of CD169<jats:sup>+<\/jats:sup> macrophages, but required sustained IFN\u2010I responses. In turn, reduction in vesicular stomatitis virus replication in CD169<jats:sup>+<\/jats:sup> macrophages resulted in a reduction in antigen production, which is necessary for generating optimal humoral responses. This study highlights a novel mechanism by which IFN\u2010I signaling promotes an immune suppressive state during persistent viral infection.<\/jats:p>","DOI":"10.1002\/eji.201546224","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T03:40:40Z","timestamp":1453174840000},"page":"300-302","source":"Crossref","is-referenced-by-count":5,"title":["Too much of a good thing: Sustained type 1 interferon signaling limits humoral responses to secondary viral infection"],"prefix":"10.1002","volume":"46","author":[{"given":"John R.","family":"Teijaro","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbial Science The Scripps Research Institute  La Jolla CA USA"},{"name":"Department of Chemical Physiology The Scripps Research Institute  La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,3]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04444"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1492"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.03.009"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211910109"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.69.2.1059-1070.1995"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702579104"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1999.tb01300.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10624"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41264"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235214"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235208"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2169"},{"key":"e_1_2_4_14_1","first-page":"3512","article-title":"Resolution of immune activation defines nonpathogenic SIV infection","volume":"119","author":"Manches O.","year":"2009","journal-title":"J. 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