{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:41:39Z","timestamp":1786977699337,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T00:00:00Z","timestamp":1462492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K12 HD068373"],"award-info":[{"award-number":["K12 HD068373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR056702"],"award-info":[{"award-number":["R01 AR056702"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AI078907"],"award-info":[{"award-number":["P01 AI078907"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AR061307"],"award-info":[{"award-number":["P30 AR061307"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>\n                    A unique population of CD23\n                    <jats:sup>+<\/jats:sup>\n                    CD21\n                    <jats:sup>high<\/jats:sup>\n                    <jats:styled-content>B<\/jats:styled-content>\n                    cells in\n                    <jats:styled-content>i<\/jats:styled-content>\n                    nflamed\n                    <jats:styled-content>n<\/jats:styled-content>\n                    odes (Bin) has been shown to accumulate in lymph nodes (LNs) draining inflamed joints of TNF\u2010transgenic (TNF\u2010tg) mice. Bin cells contribute to arthritis flare in mice by distorting node architecture and hampering lymphatic flow, but their existence in human inflamed LNs has not yet been described. Here, we report the characterization of resident B\u2010cell populations in fresh popliteal lymph nodes (PLNs) from patients with severe lower limb diseases (non\u2010RA) and rheumatoid arthritis (RA) patients, and from banked, cryopreserved reactive and normal human LN single cell suspension samples. Bin\u2010like B cells were shown to be significantly increased in reactive LNs, and strikingly elevated (&gt;30% of total) in RA samples. Histopathology and immunofluorescence analyses were consistent with B follicular hyperplasia and histological alterations in RA vs. non\u2010RA PLNs. This is the first description of Bin\u2010like B cells in human inflamed LNs. Consistent with published mouse data, this population appears to be associated with inflammatory arthritis and distortion of LN architecture. Further analyses are necessary to assess the role of CD23\n                    <jats:sup>+<\/jats:sup>\n                    CD21\n                    <jats:sup>hi<\/jats:sup>\n                    Bin\u2010like B cells in RA pathogenesis and arthritic flare.\n                  <\/jats:p>","DOI":"10.1002\/eji.201546266","type":"journal-article","created":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T05:04:48Z","timestamp":1461387888000},"page":"1752-1757","source":"Crossref","is-referenced-by-count":24,"title":["Increased numbers of CD23\n                    <sup>+<\/sup>\n                    CD21\n                    <sup>hi<\/sup>\n                    Bin\u2010like B cells in human reactive and rheumatoid arthritis lymph nodes"],"prefix":"10.1002","volume":"46","author":[{"given":"Igor I.","family":"Kuzin","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Cooper Medical School of Rowan University  Camden NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Kates","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research University of Rochester School of Medicine and Dentistry  Rochester NY USA"},{"name":"Department of Orthopaedics University of Rochester School of Medicine and Dentistry  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Ju","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research University of Rochester School of Medicine and Dentistry  Rochester NY USA"},{"name":"Department of Pathology and Laboratory Medicine University of Rochester School of Medicine and Dentistry  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longze","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research University of Rochester School of Medicine and Dentistry  Rochester NY USA"},{"name":"Department of Orthopaedics University of Rochester School of Medicine and Dentistry  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homaira","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research University of Rochester School of Medicine and Dentistry  Rochester NY USA"},{"name":"Department of Pediatrics University of Rochester School of Medicine and Dentistry  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Wojciechowski","sequence":"additional","affiliation":[{"name":"Center for Pediatric Biomed Research and Flow Cytometry Shared Resource Laboratory University of Rochester School of Medicine and Dentistry  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"J.P. Wilmot Cancer Center University of Rochester School of Medicine and Dentistry  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Burack","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Rochester School of Medicine and Dentistry  Rochester NY USA"},{"name":"J.P. Wilmot Cancer Center University of Rochester School of Medicine and Dentistry  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research University of Rochester School of Medicine and Dentistry  Rochester NY USA"},{"name":"Department of Orthopaedics University of Rochester School of Medicine and Dentistry  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bottaro","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Cooper Medical School of Rowan University  Camden NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283369cb8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.665526"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.062505"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111488"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb04978.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3452"},{"key":"e_1_2_7_8_1","first-page":"S684","article-title":"Synovitis and focal erosion in inflamed joints is triggered by activation and translocation of B Cells in the draining lymph node","volume":"56","author":"Proulx S.","year":"2007","journal-title":"Arthr. 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