{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:11:20Z","timestamp":1777590680647,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000032","name":"Institute of Infection and Immunity","doi-asserted-by":"publisher","award":["106623"],"award-info":[{"award-number":["106623"]}],"id":[{"id":"10.13039\/501100000032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000032","name":"Institute of Infection and Immunity","doi-asserted-by":"publisher","award":["89773"],"award-info":[{"award-number":["89773"]}],"id":[{"id":"10.13039\/501100000032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1104433"],"award-info":[{"award-number":["APP1104433"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1104466"],"award-info":[{"award-number":["APP1104466"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Proinflammatory cytokines produced during immune responses to infectious stimuli are well\u2010characterized to have secondary effects on the function of hematopoietic progenitor cells in the BM. However, these effects on the BM are poorly characterized during chronic infection with intestinal helminth parasites. In this study, we use the <jats:italic>Trichuris muris<\/jats:italic> model of infection and show that Th1 cell\u2010associated, but not acute Th2 cell\u2010associated, responses to chronic <jats:italic>T. muris<\/jats:italic> infection cause a major, transient expansion of CD48<jats:sup>\u2212<\/jats:sup>CD150<jats:sup>\u2212<\/jats:sup> multipotent progenitor cells in the BM that is dependent on the presence of adaptive immune cells and IFN\u2010\u03b3 signaling. Chronic <jats:italic>T. muris<\/jats:italic> infection also broadly stimulated proliferation of BM progenitor cells including CD48<jats:sup>\u2212<\/jats:sup>CD150<jats:sup>+<\/jats:sup> hematopoietic stem cells. This shift in progenitor activity during chronic <jats:italic>T. muris<\/jats:italic> infection correlated with a functional increase in myeloid colony formation in vitro as well as neutrophilia in the BM and peripheral blood. In parallel, we observed an accumulation of CD4<jats:sup>+<\/jats:sup>, CD8<jats:sup>+<\/jats:sup>, and CD4<jats:sup>\u2212<\/jats:sup>CD8<jats:sup>\u2212<\/jats:sup> (double negative) T cells that expressed IFN\u2010\u03b3, displaying activated and central memory\u2010type phenotypes in the bone marrow during chronic infection. Thus, these results demonstrate that Th1 cell\u2010driven responses in the intestine during chronic helminth infection potently influence upstream hematopoietic processes in the BM via IFN\u2010\u03b3.<\/jats:p>","DOI":"10.1002\/eji.201646326","type":"journal-article","created":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T03:20:31Z","timestamp":1473045631000},"page":"2587-2596","source":"Crossref","is-referenced-by-count":16,"title":["Chronic <i>Trichuris muris<\/i> infection alters hematopoiesis and causes IFN\u2010\u03b3\u2010expressing T\u2010cell accumulation in the mouse bone marrow"],"prefix":"10.1002","volume":"46","author":[{"given":"Alistair L.","family":"Chenery","sequence":"first","affiliation":[{"name":"The Biomedical Research Centre University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frann","family":"Antignano","sequence":"additional","affiliation":[{"name":"The Biomedical Research Centre University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Hughes","sequence":"additional","affiliation":[{"name":"The Biomedical Research Centre University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Burrows","sequence":"additional","affiliation":[{"name":"The Biomedical Research Centre University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly M.","family":"McNagny","sequence":"additional","affiliation":[{"name":"The Biomedical Research Centre University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colby","family":"Zaph","sequence":"additional","affiliation":[{"name":"The Biomedical Research Centre University of British Columbia  Vancouver Canada"},{"name":"Infection and Immunity Program Monash Biomedicine Discovery Institute Monash University  Clayton Victoria Australia"},{"name":"Department of Biochemistry and Molecular Biology School of Biomedical Sciences Monash University  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302061"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.027"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003438"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-568451"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001893"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09135"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-432906"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400669"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.025"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34261"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/498219"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4297\/najms.2011.330"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0348-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.252"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.05.014"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(04)57004-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.5.2383"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3010"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.8.2914.2914_2914_2924"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-367706"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01240-15"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.09.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.10.2628.2628"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1227-10.2010"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1098"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.04.011"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050569"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.91"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004396"},{"key":"e_1_2_7_31_1","first-page":"2774","article-title":"Trichuris muris infection: a model of type 2 immunity and inflammation in the gut","volume":"51","author":"Antignano F.","year":"2011","journal-title":"J. Vis. Exp."}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201646326","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201646326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:23:25Z","timestamp":1695713005000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201646326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,26]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/eji.201646326"],"URL":"https:\/\/doi.org\/10.1002\/eji.201646326","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,26]]}}}