{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:03:33Z","timestamp":1791389013863,"version":"4.3.3"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005696","name":"Universit\u00e9 d'Orl\u00e9ans","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005696","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_152638"],"award-info":[{"award-number":["310030_152638"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Allergic asthma is characterized by a strong Th2 response with inflammatory cell recruitment and structural changes in the lung. Papain is a protease allergen disrupting the airway epithelium triggering a rapid inflammation with eosinophilia mediated by innate lymphoid cell activation (ILC2) and leading to a Th2 immune response. In this study, we focused on inflammatory responses to a single exposure to papain and showed that intranasal administration of papain results in the recruitment of inflammatory cells, including neutrophils and eosinophils with a rapid production of IL\u20101\u03b1, IL\u20101\u03b2, and IL\u201033. The inflammatory response is abrogated in the absence of IL\u20101R1 and MyD88. To decipher the cell type(s) involved in MyD88\u2010dependent IL\u20101R1\/MyD88 signaling, we used new cell\u2010specific MyD88\u2010deficient mice and found that the deletion of MyD88 signaling in single cell types such as T cells, epithelial cells, CD11c\u2010positive or myeloid cells leads to only a partial inhibition compared to complete absence of MyD88, suggesting that several cell types contribute to the response. Importantly, the inflammatory response is largely ST2 and IL\u201036R independent. In conclusion, IL\u20101R1 signaling via MyD88 is critical for the first step of inflammatory response to papain.<\/jats:p>","DOI":"10.1002\/eji.201646366","type":"journal-article","created":{"date-parts":[[2016,8,28]],"date-time":"2016-08-28T22:23:03Z","timestamp":1472422983000},"page":"2531-2541","source":"Crossref","is-referenced-by-count":32,"title":["IL\u20101R1\u2013MyD88 axis elicits papain\u2010induced lung inflammation"],"prefix":"10.1002","volume":"46","author":[{"given":"Rafiou","family":"Agoro","sequence":"first","affiliation":[{"name":"Experimental and Molecular Immunology and Neurogenetics University of Orleans  CNRS, UMR7355 Orleans France"},{"name":"Institute of Infectious Disease and Molecular Medicine University of Cape Town  Cape Town Republic of South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Piotet\u2010Morin","sequence":"additional","affiliation":[{"name":"Experimental and Molecular Immunology and Neurogenetics 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