{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:47:02Z","timestamp":1792000022133,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC670"],"award-info":[{"award-number":["CRC670"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC829"],"award-info":[{"award-number":["CRC829"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>The nucleotide binding and oligomerization domain\u2010like receptor (NLR) protein NLRP10 is highly expressed in the epidermis and contributes to cell\u2010autonomous responses against invasive bacteria. To investigate the role of NLRP10 in inflammatory responses of the skin we analyzed the effect of full\u2010body and keratinocyte\u2010specific depletion of NLRP10 in croton oil\u2010induced irritant contact dermatitis (ICD) and 1\u2010fluoro\u20102,4\u2010dinitrobenzene (DNFB)\u2010induced contact hypersensitivity (CHS) in mice. <jats:italic>Nlrp10<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice were phenotypically normal and skin repair after wounding was not affected by lack of NLRP10. Similarly, we did not detect a contribution of NLRP10 to the ICD response induced by croton oil. In contrast, <jats:italic>Nlrp10<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice showed significantly reduced inflammation in the DNFB\u2010induced CHS response as compared to control animals. Microscopic analysis revealed significantly reduced numbers of CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells in the infiltrates of animals lacking NLRP10 expression after CHS challenge. Epidermis\u2010specific deletion of <jats:italic>Nlrp10<\/jats:italic> by keratin\u201014 promotor driven Cre\u2010recombinase was sufficient to account for this phenotype, although lymphocyte recruitment seemed to be unaltered in animals lacking NLRP10 expression in keratinocytes. Taken together, we provide evidence that NLRP10 contributes to T\u2010cell\u2010mediated inflammatory responses in the skin and highlight a physiological role of NLRP10 in epidermal keratinocytes.<\/jats:p>","DOI":"10.1002\/eji.201646401","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T08:10:39Z","timestamp":1464163839000},"page":"1959-1969","source":"Crossref","is-referenced-by-count":34,"title":["Epidermal NLRP10 contributes to contact hypersensitivity responses in mice"],"prefix":"10.1002","volume":"46","author":[{"given":"Anna","family":"Damm","sequence":"first","affiliation":[{"name":"Institute for Medical Microbiology Immunology and Hygiene University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nives","family":"Giebeler","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Zamek","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Zigrino","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Kufer","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology Immunology and Hygiene University of Cologne  Cologne Germany"},{"name":"Institute of Nutritional Medicine Department of Immunology University of Hohenheim  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.10.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1206756"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00048.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.08.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00486"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.01.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.03.006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.01.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2012.01822.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh081"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201715"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11012"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501554112"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900779"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-11-r130"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2438"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.24.5080"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700701"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12358"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.239"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3646"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20016"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32833e08ae"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.4.1398"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3283088cf9"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002337"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0304193"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.04.029"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.10.1441"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.284"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002227"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201646401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201646401","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201646401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T21:00:11Z","timestamp":1696539611000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201646401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,16]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1002\/eji.201646401"],"URL":"https:\/\/doi.org\/10.1002\/eji.201646401","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,16]]}}}