{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:44:11Z","timestamp":1790775851605,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T00:00:00Z","timestamp":1476748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000142","name":"Arthritis Society","doi-asserted-by":"publisher","award":["RG\u201010\u2010012"],"award-info":[{"award-number":["RG\u201010\u2010012"]}],"id":[{"id":"10.13039\/501100000142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000033","name":"Institute of Musculoskeletal Health and Arthritis","doi-asserted-by":"publisher","award":["MUS\u201094027"],"award-info":[{"award-number":["MUS\u201094027"]}],"id":[{"id":"10.13039\/501100000033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Monocytes are central to the physiopathology of arthritis, but their roles in progression and resolution of the disease remain to be clarified. Using NR4A1<jats:sup>\u2212\/\u2212<\/jats:sup> mice, which lack patrolling lymphocyte antigen 6C (Ly6C<jats:sup>low<\/jats:sup>) monocytes, we found that inflammatory Ly6C<jats:sup>high<\/jats:sup> monocytes contribute to rapid development of arthritis in a serum transfer\u2010induced arthritis (STIA) model. Our experiments suggest that patrolling monocytes do not promote the initiation and progression of arthritis in mice, as severity of symptoms was amplified in NR4A1<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Moreover, we show that treatment of arthritic wild type (WT) mice with cytosporone B (Csn\u2010B), a NR4A1\u2010specific agonist, significantly reduces severity of disease. Effects of Csn\u2010B were absent in monocyte\u2010depleted mice treated with clodronate until Ly6C<jats:sup>low<\/jats:sup> monocytes were restored. Adoptive transfer of Ly6C<jats:sup>low<\/jats:sup> monocytes in arthritic NR4A1<jats:sup>\u2212\/\u2212<\/jats:sup> mice treated with Csn\u2010B reduces joint inflammation, supporting the regulatory role of Ly6C<jats:sup>low<\/jats:sup> subset on disease development. Our results also reveal that administration of Csn\u2010B to arthritic mice enhances levels of circulating CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>FoxP3<jats:sup>+<\/jats:sup> Treg cells, a process requiring the presence of Ly6C<jats:sup>low<\/jats:sup> monocytes. Together, these data indicate that Ly6C<jats:sup>high<\/jats:sup> monocytes are involved in the initiation and progression of arthritis and Ly6C<jats:sup>low<\/jats:sup> monocytes contribute to reduce joint inflammation through the mobilization of Treg cells.<\/jats:p>","DOI":"10.1002\/eji.201646406","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T15:38:50Z","timestamp":1473262730000},"page":"2789-2800","source":"Crossref","is-referenced-by-count":53,"title":["NR4A1\u2010dependent Ly6C<sup>low<\/sup> monocytes contribute to reducing joint inflammation in arthritic mice through Treg cells"],"prefix":"10.1002","volume":"46","author":[{"given":"Alexandre","family":"Brunet","sequence":"first","affiliation":[{"name":"Laboratory of Innate Immunology Centre de recherche du CHU de Qu\u00e9bec\u2014Universit\u00e9 Laval  Qu\u00e9bec QC 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