{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:46:51Z","timestamp":1778600811060,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["13GW0099; key project D5"],"award-info":[{"award-number":["13GW0099; key project D5"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>CD40\u2010CD40 ligand (CD40L) signaling plays multiple indispensable roles in cellular and humoral immunity. Impaired memory T\u2010cell responses in the absence of CD40L have been well documented, but the requirement of this interaction for efficient priming of CD8<jats:sup>+<\/jats:sup> T\u00a0cells especially under inflammatory conditions has been under debate. In contrast to previous publications, we report here that virus\u2010specific CD8<jats:sup>+<\/jats:sup> T\u2010cell responses as well as viral clearance are affected not only in the memory but also in the effector phase in CD40L<jats:sup>\u2212\/\u2212<\/jats:sup> mice infected with lymphocytic choriomeningitis virus (LCMV) Armstrong strain. Interestingly, a considerable part of the LCMV\u2010specific effector and memory T\u00a0cells consists of CD40L<jats:sup>+<\/jats:sup> CD8<jats:sup>+<\/jats:sup> T\u00a0cells. However, deficiency of CD40L in CD8<jats:sup>+<\/jats:sup> T\u00a0cells did influence neither the quantity nor the quality of primary T\u2010cell responses in LCMV infection. Virus\u2010specific CD8<jats:sup>+<\/jats:sup> T\u00a0cells in conditional knockout mice, with a selective deletion of the <jats:italic>CD40L<\/jats:italic> in CD8<jats:sup>+<\/jats:sup> T\u00a0cells, were fully functional regarding cytokine production and efficient pathogen clearance. Thus, our results unambiguously demonstrate that while CD40L is critical to generate effective primary CD8<jats:sup>+<\/jats:sup> T\u2010cell responses also under inflammatory conditions, CD40L expression by CD8<jats:sup>+<\/jats:sup> T\u00a0cells themselves is dispensable in acute LCMV infection.<\/jats:p>","DOI":"10.1002\/eji.201646420","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T08:24:04Z","timestamp":1472199844000},"page":"2566-2573","source":"Crossref","is-referenced-by-count":14,"title":["CD40L expression by CD4<sup>+<\/sup> but not CD8<sup>+<\/sup> T\u00a0cells regulates antiviral immune responses in acute LCMV infection in mice"],"prefix":"10.1002","volume":"46","author":[{"given":"Sibel","family":"Durlanik","sequence":"first","affiliation":[{"name":"Regenerative Immunology and Aging Berlin\u2010Brandenburger Center for Regenerative Therapies (BCRT) Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Cellular 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