{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:15:58Z","timestamp":1790248558246,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T00:00:00Z","timestamp":1476144000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K01207X\/1"],"award-info":[{"award-number":["MR\/K01207X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M011542\/1"],"award-info":[{"award-number":["MR\/M011542\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>IL\u201033 plays an important role in the initiation of type\u20102 immune responses, as well as the enhancement of type 2 effector functions. Engagement of the IL\u201033 receptor on macrophages facilitates polarization to an alternative activation state by amplifying IL\u20104 and IL\u201013 signaling to IL\u20104R\u03b1. IL\u20104 and IL\u201013 also induce macrophage proliferation but IL\u201033 involvement in this process has not been rigorously evaluated. As expected, in vivo delivery of IL\u201033 induced IL\u20104R\u03b1\u2010dependent alternative macrophage activation in the serous cavities. IL\u201033 delivery also induced macrophages to proliferate but, unexpectedly, this was independent of IL\u20104R\u03b1 signaling. In a filarial nematode infection model in which IL\u20104R\u03b1\u2010dependent alternative activation and proliferation in the pleural cavity is well described, IL\u201033R was essential for alternative activation but not macrophage proliferation. Similarly, during <jats:italic>Alternaria alternata<\/jats:italic> induced airway inflammation, which provokes strong IL\u201033 responses, we observed that both IL\u20104R\u03b1 and IL\u201033R were required for alternative activation, while macrophage proliferation in the pleural cavity was still evident in the absence of either receptor alone. Our data show that IL\u201033R and IL\u20104R\u03b1 promote macrophage proliferation independently of each other, but both are essential for induction of alternative activation.<\/jats:p>","DOI":"10.1002\/eji.201646442","type":"journal-article","created":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T08:28:41Z","timestamp":1473064121000},"page":"2311-2321","source":"Crossref","is-referenced-by-count":36,"title":["IL\u201033 delivery induces serous cavity macrophage proliferation independent of interleukin\u20104 receptor alpha"],"prefix":"10.1002","volume":"46","author":[{"given":"Lucy H.","family":"Jackson\u2010Jones","sequence":"first","affiliation":[{"name":"School of Biological Sciences University of Edinburgh  Edinburgh EH9 3FL UK"},{"name":"Centre for Cardiovascular Science University of Edinburgh  Edinburgh EH16 4TJ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"R\u00fcckerl","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Edinburgh  Edinburgh EH9 3FL UK"},{"name":"Faculty of Biology, Medicine &amp; Health University of Manchester  Manchester M13 9PT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freya","family":"Svedberg","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine &amp; Health University of Manchester  Manchester M13 9PT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheelagh","family":"Duncan","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Edinburgh  Edinburgh EH9 3FL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick M.","family":"Maizels","sequence":"additional","affiliation":[{"name":"Institute of Infection Immunity &amp; Inflammation University of Glasgow  Glasgow G12 8TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara E.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Edinburgh  Edinburgh EH9 3FL UK"},{"name":"Faculty of Biology, Medicine &amp; Health University of Manchester  Manchester M13 9PT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research University of Edinburgh  Edinburgh EH16 4TJ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry J.","family":"McSorley","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Edinburgh  Edinburgh EH9 3FL UK"},{"name":"Centre for Inflammation Research University of Edinburgh  Edinburgh EH16 4TJ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"B\u00e9n\u00e9zech","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science University of Edinburgh  Edinburgh EH16 4TJ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine &amp; Health University of Manchester  Manchester M13 9PT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith E.","family":"Allen","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Edinburgh  Edinburgh EH9 3FL UK"},{"name":"Faculty of Biology, Medicine &amp; Health University of Manchester  Manchester M13 9PT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0224RC"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204351"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.04.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1242974"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-379214"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121999"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.09.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000730"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444969"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1201475"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.066"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304046110"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901575"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003487"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004607"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.12.020"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141817"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-3-7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-442640"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.3.1235"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12651"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003020"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242863"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.123"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300426"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.011"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/250938"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093072"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12221"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.161.6.1554"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12312"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.06.006"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-009-9165-3"},{"key":"e_1_2_7_35_1","first-page":"981","article-title":"Tuberculous pleural effusions: advances and controversies","volume":"7","author":"Vorster M. J.","year":"2015","journal-title":"J Thorac Dis"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20130769"},{"key":"e_1_2_7_37_1","first-page":"1021","article-title":"Pleural involvement in lung cancer","volume":"7","author":"Agalioti T.","year":"2015","journal-title":"J Thorac Dis"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020656"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201646442","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201646442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T16:26:08Z","timestamp":1696609568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201646442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1002\/eji.201646442"],"URL":"https:\/\/doi.org\/10.1002\/eji.201646442","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10]]}}}