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It also enables T\u2010cell expansion in neonates, and after depletion by chemotherapy, bone marrow transplantation, or infection. The same signals required for T\u2010cell survival in lymphoreplete settings, IL\u20107 and T\u2010cell receptor (TCR) interactions with self\u2010peptide MHC (pMHC), induce division when T\u2010cell numbers are low. The strength of reactivity for self\u2010pMHC has been shown to correlate with the capacity of T cells to undergo lymphopenia\u2010induced proliferation (LIP), in that weakly self\u2010reactive T cells are unable to divide, implying that T\u2010cell reconstitution would significantly skew the TCR repertoire toward TCRs with greater self\u2010reactivity and thus compromise T\u2010cell diversity. Here, we show that while CD4<jats:sup>+<\/jats:sup> T cells with low self\u2010pMHC reactivity experience more intense competition, they are able to divide when present at low enough cell numbers. Thus, at physiological precursor frequencies CD4<jats:sup>+<\/jats:sup> T cells with low self\u2010pMHC reactivity are able to contribute to the reconstitution of the T\u2010cell pool.<\/jats:p>","DOI":"10.1002\/eji.201646540","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T12:53:55Z","timestamp":1477659235000},"page":"68-73","source":"Crossref","is-referenced-by-count":12,"title":["Weakly self\u2010reactive T\u2010cell clones can homeostatically expand when present at low numbers"],"prefix":"10.1002","volume":"47","author":[{"given":"Nienke","family":"Vrisekoop","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Laboratory of Translational Immunology University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricio","family":"Artusa","sequence":"additional","affiliation":[{"name":"Department of Physiology Complex Traits Group McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joao P.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Lymphocyte Biology Section Laboratory of Systems Biology National Institute of Allergy and Infectious Diseases National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith N.","family":"Mandl","sequence":"additional","affiliation":[{"name":"Department of Physiology Complex Traits Group McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.02.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.11.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2657"},{"key":"e_1_2_7_5_1","first-page":"1","article-title":"Homeostasis of T cell diversity","volume":"2","author":"Mahajan V. 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