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Resolution of inflammation is an active process leading to restoration of tissue homeostasis. Here, we studied the role of Annexin A1 (AnxA1), a glucocorticoid\u2010regulated protein that has anti\u2010inflammatory and proresolving actions, in resolution of acute gouty inflammation. Injection of MSU crystals in the knee joint of mice induced inflammation that was associated with expression of AnxA1 during the resolving phase of inflammation. Neutralization of AnxA1 with antiserum or blockade of its receptor with BOC\u20101 (nonselective) or WRW<jats:sub>4<\/jats:sub> (selective) prevented the spontaneous resolution of gout. There was greater neutrophil infiltration after challenge with MSU crystals in AnxA1 knockout mice (AnxA1<jats:sup>\u2212\/\u2212<\/jats:sup>) and delayed resolution associated to decreased neutrophil apoptosis and efferocytosis. Pretreatment of mice with AnxA1\u2010active N\u2010terminal peptide (Ac<jats:sub>2\u201326<\/jats:sub>) decreased neutrophil influx, IL\u20101\u03b2, and CXCL1 production in periarticular joint. Posttreatment with Ac<jats:sub>2\u201326<\/jats:sub> decreased neutrophil accumulation, IL\u20101\u03b2, and hypernociception, and improved the articular histopathological score. Importantly, the therapeutic effects of Ac<jats:sub>2\u201326<\/jats:sub> were associated with increased neutrophils apoptosis and shortened resolution intervals. In conclusion, AnxA1 plays a crucial role in the context of acute gouty inflammation by promoting timely resolution of inflammation.<\/jats:p>","DOI":"10.1002\/eji.201646551","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T04:22:44Z","timestamp":1482207764000},"page":"585-596","source":"Crossref","is-referenced-by-count":70,"title":["Annexin A1 promotes timely resolution of inflammation in murine gout"],"prefix":"10.1002","volume":"47","author":[{"given":"Izabela","family":"Galv\u00e3o","sequence":"first","affiliation":[{"name":"Imunofarmacologia Departamento de Bioqu\u00edmica e Imunologia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana P.","family":"Vago","sequence":"additional","affiliation":[{"name":"Imunofarmacologia Departamento de Bioqu\u00edmica e Imunologia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Departamento de Morfologia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia C.","family":"Barroso","sequence":"additional","affiliation":[{"name":"Imunofarmacologia Departamento de Bioqu\u00edmica e Imunologia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana P.","family":"Tavares","sequence":"additional","affiliation":[{"name":"Imunofarmacologia Departamento de Bioqu\u00edmica e Imunologia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso M.","family":"Queiroz\u2010Junior","sequence":"additional","affiliation":[{"name":"Departamento de Morfologia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian V.","family":"Costa","sequence":"additional","affiliation":[{"name":"Imunofarmacologia Departamento de Bioqu\u00edmica e Imunologia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda S.","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana P.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o Instituto Oswaldo Cruz\/FIOCRUZ  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M. 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