{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:35:43Z","timestamp":1791318943279,"version":"4.3.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_132492\/1"],"award-info":[{"award-number":["310030_132492\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Th17 cells are often associated with autoimmunity and been shown to be increased in CD11b<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Here, we examined the role of CD11b in murine collagen\u2010induced arthritis (CIA). C57BL\/6 and CD11b<jats:sup>\u2212\/\u2212<\/jats:sup> resistant mice were immunized with type II collagen. CD11b<jats:sup>\u2212\/\u2212<\/jats:sup> mice developed arthritis with early onset, high incidence, and sustained severity compared with C57BL\/6 mice. We observed a marked leukocyte infiltration, and histological examinations of the arthritic paws from CD11b<jats:sup>\u2212\/\u2212<\/jats:sup> mice revealed that the cartilage was destroyed in association with strong lymphocytic infiltration. The CD11b deficiency led to enhanced Th17\u2010cell differentiation. CD11b<jats:sup>\u2212\/\u2212<\/jats:sup> dendritic cells (DCs) induced much stronger IL\u20106 production and hence Th17\u2010cell differentiation than wild\u2010type DCs. Treatment of CD11b<jats:sup>\u2212\/\u2212<\/jats:sup> mice after establishment of the Treg\/Th17 balance with an anti\u2010IL\u20106 receptor mAb significantly suppressed the induction of Th17 cells and reduced arthritis severity. Finally, the severe phenotype of arthritis in CD11b<jats:sup>\u2212\/\u2212<\/jats:sup> mice was rescued by adoptive transfer of CD11b<jats:sup>+<\/jats:sup> DCs. Taken together, our results indicate that the resistance to CIA in C57BL\/6 mice is regulated by CD11b via suppression of IL\u20106 production leading to reduced Th17\u2010cell differentiation. Therefore, CD11b may represent a susceptibility factor for autoimmunity and could be a target for future therapy.<\/jats:p>","DOI":"10.1002\/eji.201646565","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T04:22:44Z","timestamp":1486959764000},"page":"637-645","source":"Crossref","is-referenced-by-count":38,"title":["CD11b regulates the Treg\/Th17 balance in murine arthritis via IL\u20106"],"prefix":"10.1002","volume":"47","author":[{"given":"Mathias","family":"Stevanin","sequence":"first","affiliation":[{"name":"Department of Biochemistry CIIL University of Lausanne  Epalinges Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Busso","sequence":"additional","affiliation":[{"name":"DAL, Service of Rheumatology Laboratory of Rheumatology University of Lausanne  CHUV Epalinges Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Chobaz","sequence":"additional","affiliation":[{"name":"DAL, Service of Rheumatology Laboratory of Rheumatology University of Lausanne  CHUV Epalinges Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pigni","sequence":"additional","affiliation":[{"name":"Department of Biochemistry CIIL University of Lausanne  Epalinges Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Ghassem\u2010Zadeh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry CIIL University of Lausanne  Epalinges Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Vascular and Inflammatory Diseases Department of Physiology University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Acha\u2010Orbea","sequence":"additional","affiliation":[{"name":"Department of Biochemistry CIIL University of Lausanne  Epalinges Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Driss","family":"Ehirchiou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry CIIL University of Lausanne  Epalinges Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.3.688"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.4049\/jimmunol.135.4.2443","article-title":"Type II collagen\u2010induced arthritis in mice. 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