{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T07:40:49Z","timestamp":1695800449414},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>How the immune system maintains peripheral tolerance under inflammatory conditions is poorly understood. Here we assessed the fate of gastritogenic T cells following inflammatory activation in vivo. Self\u2010reactive T cells (A23 T cells) specific for the gastric H<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup> ATPase \u03b1 subunit (HK\u03b1) were transferred into immunosufficient recipient mice and immunised at a site distant to the stomach with adjuvant containing the cognate HK\u03b1 peptide antigen. Activation of A23 T cells by immunisation did not impact on either immune tolerance or protection from gastric autoimmunity in wild\u2010type BALB\/c mice. However, increased presentation of endogenously derived HK\u03b1\u00a0epitopes by dendritic cells (DCs) in the gastric lymph node of IE\u2010H<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>\u03b2 transgenic mice (IE\u03b2) reduces A23 T\u2010cell tolerance to gastric antigens after inflammatory activation, with subsequent development of gastritis. While HK\u03b1\u2010specific A23 T cells from immunised wild\u2010type mice were poorly responsive to in vitro antigen specific activation, A23 T cells from immunised IE\u03b2 transgenic mice were readily re\u2010activated, indicating loss of T\u2010cell anergy. These findings show that DCs of gastric lymph nodes can maintain tolerance of pathogenic T cells following inflammatory stimulation and that the density of endogenous antigen presented to self\u2010reactive T cells is critical in the balance between tolerance and autoimmunity.<\/jats:p>","DOI":"10.1002\/eji.201646572","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T09:22:40Z","timestamp":1476868960000},"page":"155-167","source":"Crossref","is-referenced-by-count":0,"title":["Increased endogenous antigen presentation in the periphery enhances susceptibility to inflammation\u2010induced gastric autoimmunity in mice"],"prefix":"10.1002","volume":"47","author":[{"given":"Sarah A.","family":"Overall","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology Institute the University of Melbourne  Melbourne 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