{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T02:14:26Z","timestamp":1782267266368,"version":"3.54.5"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004738","name":"UBS","doi-asserted-by":"publisher","award":["#3274"],"award-info":[{"award-number":["#3274"]}],"id":[{"id":"10.13039\/100004738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Co\u2010infections of influenza virus and bacteria are known to cause severe disease, but little information exists on co\u2010infections with other acute viruses. Seasonal influenza and dengue viruses (DENV) regularly co\u2010circulate in tropical regions. The pandemic spread of influenza virus H1N1 (hereafter H1N1) in 2009 led to additional severe disease cases that were co\u2010infected with DENV. Here, we investigated the impact of co\u2010infection on immune responses and pathogenesis in a new mouse model. Co\u2010infection of otherwise sublethal doses of a Nicaraguan clinical H1N1 isolate and two days later with a virulent DENV2 strain increased systemic DENV titers and caused 90% lethality. Lungs of co\u2010infected mice carried both viruses, developed severe pneumonia, and expressed a unique pattern of host mRNAs, resembling only partial responses against infection with either virus alone. A large number of monocytes were recruited to DENV\u2010infected but not to co\u2010infected lungs, and depletion and adoptive transfer experiments revealed a beneficial role of monocytes. Our study shows that co\u2010infection with influenza and DENV impairs host responses, which fail to control DENV titers and instead, induce severe lung damage. Further, our findings identify key inflammatory pathways and monocyte function as targets for future therapies that may limit immunopathology in co\u2010infected patients.<\/jats:p>","DOI":"10.1002\/eji.201646675","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T07:52:45Z","timestamp":1482220365000},"page":"527-539","source":"Crossref","is-referenced-by-count":23,"title":["Influenza and dengue virus co\u2010infection impairs monocyte recruitment to the lung, increases dengue virus titers, and exacerbates pneumonia"],"prefix":"10.1002","volume":"47","author":[{"given":"Michael A.","family":"Schmid","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Vaccinology School of Public Health University of California  Berkeley CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla N.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Vaccinology School of Public Health University of California  Berkeley CA USA"},{"name":"Laboratorio Nacional de Virolog\u00eda Centro Nacional de Diagn\u00f3stico y Referencia Ministerio de Salud  Managua Nicaragua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjana","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Vaccinology School of Public Health University of California  Berkeley CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Lawrence Livermore National Laboratory  Livermore CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Mack","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B.","family":"Talarico","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n INFANT  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando P.","family":"Polack","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n INFANT  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Vaccinology School of Public Health University of California  Berkeley CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1605.091920"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/INF.0b013e3181e6c69b","article-title":"Severe coinfections of dengue and pandemic influenza A H1N1 viruses","volume":"29","author":"Perez M. 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