{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:23:22Z","timestamp":1790832202787,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T00:00:00Z","timestamp":1481068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PI 295\/7\u20101"],"award-info":[{"award-number":["PI 295\/7\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>The salivary glands (SGs) of virus\u2010immune mice contain substantial numbers of tissue\u2010resident memory CD8<jats:sup>+<\/jats:sup> T cells (T<jats:sub>RM<\/jats:sub> cells) that can provide immunity to local infections. Integrins regulate entry of activated T cells into nonlymphoid tissues but the molecules that mediate migration of virus\u2010specific CD8<jats:sup>+<\/jats:sup> T cells to the SGs have not yet been defined. Here, we found that polyinosinic\u2010polycytidylic acid (poly(I:C)) strongly promoted the accumulation of P14 TCR\u2010transgenic CD8<jats:sup>+<\/jats:sup> T<jats:sub>RM<\/jats:sub> cells in SGs in an \u03b1<jats:sub>4<\/jats:sub>\u03b2<jats:sub>1<\/jats:sub> integrin\u2010dependent manner. After infection with lymphocytic choriomeningitis virus, accumulation of P14 T<jats:sub>RM<\/jats:sub> cells in SGs and intestine but not in kidney was also \u03b1<jats:sub>4<\/jats:sub> integrin dependent. Blockade of \u03b1<jats:sub>4<\/jats:sub>\u03b2<jats:sub>7<\/jats:sub> by monoclonal antibodies (mAbs) inhibited lymphocytic choriomeningitis virus\u2010induced accumulation of P14 T<jats:sub>RM<\/jats:sub> cells in the intestine but not in SGs. In conclusion, our data reveal that \u03b1<jats:sub>4<\/jats:sub>\u03b2<jats:sub>1<\/jats:sub> integrin mediates CD8<jats:sup>+<\/jats:sup> T<jats:sub>RM<\/jats:sub> accumulation in SGs and that poly(I:C) can be used to direct activated CD8<jats:sup>+<\/jats:sup> T cells to this organ.<\/jats:p>","DOI":"10.1002\/eji.201646722","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T15:32:28Z","timestamp":1479310348000},"page":"244-250","source":"Crossref","is-referenced-by-count":26,"title":["\u03b1<sub>4<\/sub>\u03b2<sub>1<\/sub> integrin promotes accumulation of tissue\u2010resident memory CD8<sup>+<\/sup> T cells in salivary glands"],"prefix":"10.1002","volume":"47","author":[{"given":"Sandra","family":"Woyciechowski","sequence":"first","affiliation":[{"name":"Institute for Immunology University Medical Center Freiburg  Freiburg Germany"},{"name":"Faculty of Biology Albert Ludwigs University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Institute for Immunology University Medical Center Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[{"name":"Institute for Immunology University Medical Center Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1718"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343519"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107200108"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090858"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11522"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010201107"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3108"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200402"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.076"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.082"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v29.i2.10"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90305-A"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.152.7.3282"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.4049\/jimmunol.163.8.4125","article-title":"Induction and visualization of mucosal memory CD8 T cells following systemic virus infection","volume":"163","author":"Kim S. 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