{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T12:41:57Z","timestamp":1696768917734},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["WA 2765\/3\u20101"],"award-info":[{"award-number":["WA 2765\/3\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The chronic, destructive autoimmune arthritis in SKG mice, which closely resembles human rheumatoid arthritis, is the result of self\u2010reactive T cells escaping thymic deletion. Since the inhibitory receptor LIR\u20101 is up\u2010regulated on auto\u2010reactive T cells in human rheumatoid arthritis, the role of its murine ortholog PIR\u2010B was investigated. Peripheral CD4<jats:sup>+<\/jats:sup> T cells from SKG mice were found to frequently express PIR\u2010B, and this population produces more frequently IL\u201017 upon in vitro stimulation compared to PIR\u2010B<jats:sup>\u2212<\/jats:sup> cells. A much larger fraction of PIR\u2010B<jats:sup>+<\/jats:sup> T cells, however, was found to secret no IL\u201017, but IFN\u2010\u03b3. With regards to the clinical course of the disease, high frequencies of PIR\u2010B<jats:sup>+<\/jats:sup> CD4<jats:sup>+<\/jats:sup> T cells were found to be associated with a milder course of arthritis, suggesting that the net effect of PIR\u2010B expression is suppression of autoreactive T cells. Our results indicate that overexpression of PIR\u2010B on IL\u201017\u2010producing SKG CD4<jats:sup>+<\/jats:sup> T cells might represent an effective counter\u2010regulatory mechanism against the destructive potential of those cells. More importantly, a major population of PIR\u2010B<jats:sup>+<\/jats:sup> T cells in SKG mice appears to play an inhibitory role by way of their IFN\u2010\u03b3 production, since high frequencies of those cells ameliorate the disease.<\/jats:p>","DOI":"10.1002\/eji.201646747","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T07:53:25Z","timestamp":1498809205000},"page":"1457-1467","source":"Crossref","is-referenced-by-count":6,"title":["Autoimmune arthritis induces paired immunoglobulin\u2010like receptor B expression on CD4<sup>+<\/sup> T\u00a0cells from SKG mice"],"prefix":"10.1002","volume":"47","author":[{"given":"Kathrin","family":"Rothe","sequence":"first","affiliation":[{"name":"University of Leipzig, Department of Internal Medicine Division of Rheumatology  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Raulien","sequence":"additional","affiliation":[{"name":"University of Leipzig, Department of Internal Medicine Division of Rheumatology  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Klinikum of Fulda Institute of Pathology  Fulda Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Pierer","sequence":"additional","affiliation":[{"name":"University of Leipzig, Department of Internal Medicine Division of Rheumatology  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Quandt","sequence":"additional","affiliation":[{"name":"University of Leipzig, Department of Internal Medicine Division of Rheumatology  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Wagner","sequence":"additional","affiliation":[{"name":"University of Leipzig, Department of Internal Medicine Division of Rheumatology  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar766"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200101)44:1<13::AID-ANR3>3.0.CO;2-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118638"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/immu.200390010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000036"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093293"},{"issue":"5","key":"e_1_2_7_8_1","first-page":"S4","article-title":"The central role of T cells in rheumatoid arthritis","volume":"25","author":"Cope A. 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