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Natural killer (NK) cells play an important role in the control of CMV and CMVs have in turn developed a plethora of immunoevasion mechanisms targeting NK cells. This complex interplay can leave a long\u2010lasting imprint on the immune system in general and affect responses toward other pathogens and vaccines. This review aims to provide an overview of NK cell biology and development, the manipulation of NK cells by CMVs and the potential impact of these evasion strategies on responses to vaccination.<\/jats:p>","DOI":"10.1002\/eji.201646762","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T11:48:16Z","timestamp":1506599296000},"page":"50-65","source":"Crossref","is-referenced-by-count":80,"title":["CMV and natural killer cells: shaping the response to vaccination"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8963-4768","authenticated-orcid":false,"given":"Martin R.","family":"Goodier","sequence":"first","affiliation":[{"name":"Department of Immunology and Infection London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5003-3108","authenticated-orcid":false,"given":"Stipan","family":"Jonji\u0107","sequence":"additional","affiliation":[{"name":"Department for Histology and Embryology and Center for Proteomics Faculty of Medicine University of Rijeka  Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor M.","family":"Riley","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infection London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7182-8927","authenticated-orcid":false,"given":"Vanda","family":"Jurani\u0107 Lisni\u0107","sequence":"additional","affiliation":[{"name":"Department for Histology and Embryology and Center for Proteomics Faculty of Medicine University of Rijeka  Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,8]]},"reference":[{"key":"e_1_2_14_2_1","first-page":"2480","volume-title":"Fields Virology","author":"Roizman B.","year":"2007"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00426"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.020"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198906293202605"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.11.022"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.08.051"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3553"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2016.11.003"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.07.003"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-012-0263-0"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2011.05.005"},{"key":"e_1_2_14_13_1","first-page":"95","article-title":"Dynamic Regulation of NK Cell Responsiveness","volume":"395","author":"Kadri N.","year":"2016","journal-title":"Curr. 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