{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:51:28Z","timestamp":1790067088360,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K08737"],"award-info":[{"award-number":["JP16K08737"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Dendritic cell immunoreceptor (DCIR) is a C\u2010type lectin with an immunoreceptor tyrosine\u2010based inhibitory motif (ITIM). Mice lacking DCIR1 (<jats:italic>Dcir1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice) show higher susceptibility to chronic arthritis with increasing age, suggesting that DCIR1 is involved in immune modulation via its ITIM. However, the role of DCIR1 in acute immune responses is not clear. In this study, we explored its role in acute experimental hepatitis. Upon injection of <jats:sc>d<\/jats:sc>\u2010galactosamine and lipopolysaccharide, <jats:italic>Dcir1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice showed decreased mortality rates and serum levels of alanine aminotransferase. In early onset hepatitis, serum levels of TNF\u2010\u03b1, which primarily cause inflammation and hepatocyte apoptosis, were significantly lower in <jats:italic>Dcir1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice than in WT mice. In the liver of <jats:italic>Dcir1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice, influx of neutrophils and other leukocytes decreased. Consistently, the levels of neutrophil\u2010chemoattractant chemokine CXCL1\/KC, but not CXCL2\/MIP\u20102, were lower in <jats:italic>Dcir1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice than in WT mice. However, chemotaxis of <jats:italic>Dcir1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> neutrophils to CXCL1\/KC appeared normal. Pervanadate treatment induced binding of DCIR1 and Src homology region 2 domain\u2010containing phosphatase (SHP)\u20102, possibly leading to CXCL1\/KC expression. These results suggest that DCIR1 is involved in exacerbation of endotoxemic hepatitis, providing a new therapeutic target for lethal hepatitis.<\/jats:p>","DOI":"10.1002\/eji.201646814","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T03:23:17Z","timestamp":1485487397000},"page":"704-712","source":"Crossref","is-referenced-by-count":7,"title":["Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice"],"prefix":"10.1002","volume":"47","author":[{"given":"Toshifumi","family":"Ishiguro","sequence":"first","affiliation":[{"name":"Department of Animal Development and Physiology Graduate School of Biostudies Kyoto University  Yoshida\u2010Konoe, Sakyo Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Fukawa","sequence":"additional","affiliation":[{"name":"Department of Animal Development and Physiology Graduate School of Biostudies Kyoto University  Yoshida\u2010Konoe, Sakyo Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Akaki","sequence":"additional","affiliation":[{"name":"Department of Animal Development and Physiology Graduate School of Biostudies Kyoto University  Yoshida\u2010Konoe, Sakyo Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nagaoka","sequence":"additional","affiliation":[{"name":"Department of Animal Development and Physiology Graduate School of Biostudies Kyoto University  Yoshida\u2010Konoe, Sakyo Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Animal Development and Physiology Graduate School of Biostudies Kyoto University  Yoshida\u2010Konoe, Sakyo Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical Sciences Tokyo University of Science  Noda Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayo","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Animal Development and Physiology Graduate School of Biostudies Kyoto University  Yoshida\u2010Konoe, Sakyo Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Takahara","sequence":"additional","affiliation":[{"name":"Department of Animal Development and Physiology Graduate School of Biostudies Kyoto University  Yoshida\u2010Konoe, Sakyo Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101352"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021787"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2222"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2569"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.4.1973"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01633.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-004-0714-x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2013.11.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1530"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2005.10.006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-081398"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0608352"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.09.040"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.029"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1697"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500273"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.14-0079"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-015-0129-5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203451"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2002.017411.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.4049\/jimmunol.160.7.3480","article-title":"Activation of caspase 3 (CPP32)\u2010like proteases is essential for TNF\u2010\u03b1\u2010induced hepatic parenchymal cell apoptosis and neutrophil\u2010mediated necrosis in a murine endotoxin shock model","volume":"160","author":"Jaeschke H.","year":"1998","journal-title":"J. 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