{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:43:29Z","timestamp":1788900209622,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CO 457\/8\u20101, SFB TR22, A23"],"award-info":[{"award-number":["CO 457\/8\u20101, SFB TR22, A23"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2010\/A47"],"award-info":[{"award-number":["2010\/A47"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>Schistosomiasis is a nontransplacental helminth infection. Chronic infection during pregnancy suppresses allergic airway responses in offspring. We addressed the question whether in utero exposure to chronic schistosome infection (Reg phase) in mice affects B\u2010cell and T\u2010cell development. Therefore, we focused our analyses on T\u2010cell differentiation capacity induced by epigenetic changes in promoter regions of signature cytokines in offspring. Here, we show that na\u00efve T cells from offspring of schistosome infected female mice had a strong capacity to differentiate into T<jats:sub>H<\/jats:sub>1 cells, whereas T<jats:sub>H<\/jats:sub>2 differentiation was impaired. In accordance, reduced levels of histone acetylation of the IL\u20104 promoter regions were observed in na\u00efve T cells. To conclude, our mouse model revealed distinct epigenetic changes within the na\u00efve T\u2010cell compartment affecting T<jats:sub>H<\/jats:sub>2 and T<jats:sub>H<\/jats:sub>1 cell differentiation in offspring of mothers with chronic helminth infection. These findings could eventually help understand how helminths alter T\u2010cell driven immune responses induced by allergens, bacterial or viral infections, as well as vaccines.<\/jats:p>","DOI":"10.1002\/eji.201646836","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T05:28:43Z","timestamp":1488950923000},"page":"841-847","source":"Crossref","is-referenced-by-count":19,"title":["Chronic schistosomiasis during pregnancy epigenetically reprograms T\u2010cell differentiation in offspring of infected mothers"],"prefix":"10.1002","volume":"47","author":[{"given":"Kathrin","family":"Klar","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Hygiene Technische Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Perchermeier","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Hygiene Technische Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonakshi","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Hygiene Technische Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Harb","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics Philipps University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thure","family":"Adler","sequence":"additional","affiliation":[{"name":"Helmholtz Zentrum M\u00fcnchen Deutsches Forschungszentrum f\u00fcr Gesundheit und Umwelt (GmbH)  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rouzanna","family":"Istvanffy","sequence":"additional","affiliation":[{"name":"III. 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