{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:57:24Z","timestamp":1790693844993,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1104433"],"award-info":[{"award-number":["1104433"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1104466"],"award-info":[{"award-number":["1104466"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>Mast cells are innate immune cells that respond rapidly to infection in barrier tissues such as the skin and intestinal mucosa. Expulsion of parasitic worms in the gut involves a robust type 2 host response, and an acute mastocytosis is often generated at the site of infection. However, the role of mast cells in resistance to worm infections appears to be parasite specific. Mast cells are also involved in tissue repair, but the long\u2010term contribution of mast cell activation after worm expulsion has not been definitively studied. In this issue of <jats:italic>European Journal of Immunology<\/jats:italic>, Sorobetea et\u00a0al. [Eur. J. Immunol. 2017. <jats:bold>47<\/jats:bold>: 257\u2013268] demonstrate that activated mast cells persist in the large intestinal lamina propria and intraepithelial compartment long after worm expulsion, resulting in continued local and systemic presence of the mast cell protease mast cell protease 1 (MCPt\u20101) and enhanced intestinal permeability. In this commentary, we discuss these findings in the wider context of mast cell function in health and disease.<\/jats:p>","DOI":"10.1002\/eji.201646842","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T08:25:39Z","timestamp":1486715139000},"page":"236-239","source":"Crossref","is-referenced-by-count":10,"title":["Mastering gut permeability: New roles for old friends"],"prefix":"10.1002","volume":"47","author":[{"given":"Michael","family":"Bramhall","sequence":"first","affiliation":[{"name":"Infection and Immunity Program, Department of Biochemistry and Molecular Biology Monash Biomedicine Discovery Institute Monash University  Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colby","family":"Zaph","sequence":"additional","affiliation":[{"name":"Infection and Immunity Program, Department of Biochemistry and Molecular Biology Monash Biomedicine Discovery Institute Monash University  Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.07.124"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.131"},{"key":"e_1_2_4_4_1","volume-title":"Beitr\u00e4ge f\u00fcr Theorie und Praxis der histologischen F\u00e4rbung","author":"Ehrlich P.","year":"1878"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.022"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00569"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-045641"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1503"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040994"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.21507"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12090"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545613"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1231488100"},{"key":"e_1_2_4_14_1","article-title":"Mucosal mast cells are indispensable for the timely termination of Strongyloides ratti infection","author":"Reitz M.","year":"2016","journal-title":"Mucosal Immunol"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112268109"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.8.3832-3840.1998"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901841"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.2.1139"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.12.1849"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2009.00651.x"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12169"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0348-2"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(96)70013-6"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000233037"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646738"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071046"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01240-15"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-0262.2004.00481.x"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201646842","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201646842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T12:54:59Z","timestamp":1695732899000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201646842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1002\/eji.201646842"],"URL":"https:\/\/doi.org\/10.1002\/eji.201646842","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}