{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:47:32Z","timestamp":1790635652914,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIHR01A108628\u201001A\u2010A87299"],"award-info":[{"award-number":["NIHR01A108628\u201001A\u2010A87299"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CD4<jats:sup>+<\/jats:sup> tissue resident cells are an important first line of defense against viral infections in the lungs and are critical for promoting the localization of lung resident CD8<jats:sup>+<\/jats:sup> T\u00a0cells. However, relatively little is known about the signaling programs required for the development of viral\u2010specific CD4<jats:sup>+<\/jats:sup> tissue resident cells in the lungs. Recently, it was shown that signaling through the high affinity IL\u20102 receptor is required for the differentiation of lung\u2010resident Th2 memory (Trm) cells in a murine model of airway inflammation. We therefore tested if IL\u20102 signaling is also required for the development of viral antigen\u2010specific CD4<jats:sup>+<\/jats:sup> Th1 cells in the lung after i.n. infection with lymphocytic choriomeningitis virus. These studies demonstrate that Th1 CD4<jats:sup>+<\/jats:sup> T\u00a0cells also require IL\u20102 for lung Trm development. Additionally, they show that B cells potently inhibit early Th1 cell lung residency, but are required for the maintenance of a long\u2010lived population of CD4<jats:sup>+<\/jats:sup> Th1 Trm.<\/jats:p>","DOI":"10.1002\/eji.201746928","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T05:22:51Z","timestamp":1506403371000},"page":"80-86","source":"Crossref","is-referenced-by-count":50,"title":["IL\u20102 is required for the generation of viral\u2010specific CD4<sup>+<\/sup> Th1 tissue\u2010resident memory cells and B cells are essential for maintenance in the lung"],"prefix":"10.1002","volume":"48","author":[{"given":"Brian D.","family":"Hondowicz","sequence":"first","affiliation":[{"name":"Department of Immunology University of Washington School of Medicine  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Washington School of Medicine  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel J.","family":"Ruterbusch","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Washington School of Medicine  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys J.","family":"Keitany","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Washington School of Medicine  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7278-0147","authenticated-orcid":false,"given":"Marion","family":"Pepper","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Washington School of Medicine  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.031"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20142101"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1257530"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102243"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.85832"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2744"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1718"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.11.004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0483"},{"key":"e_1_2_7_12_1","volume-title":"Viral genome replication","author":"Cameron C. E.","year":"2009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216109"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1826"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.8.1315"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.09.009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400019"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902022"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802501"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.005"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131556"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201746928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201746928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:55:31Z","timestamp":1695574531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201746928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,13]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/eji.201746928"],"URL":"https:\/\/doi.org\/10.1002\/eji.201746928","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,13]]}}}