{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:03:39Z","timestamp":1789898619456,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T00:00:00Z","timestamp":1495497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 GM087136 & U01 GM111849"],"award-info":[{"award-number":["RO1 GM087136 & U01 GM111849"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["SIgN"],"award-info":[{"award-number":["SIgN"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008375","name":"Universit\u00e4t Basel","doi-asserted-by":"publisher","award":["DBM"],"award-info":[{"award-number":["DBM"]}],"id":[{"id":"10.13039\/100008375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Allergic contact dermatitis is a primarily T\u2010cell\u2010mediated inflammatory skin disease induced by exposure to small molecular\u2010weight haptens, which covalently bind to proteins. The abundance of cutaneous T cells that recognize CD1a antigen\u2010presenting molecules raises the possibility that MHC\u2010independent antigen presentation may be relevant in some hapten\u2010driven immune responses. Here we examine the ability of contact sensitizers to influence CD1\u2010restricted immunity. Exposure of human antigen\u2010presenting cells such as monocyte\u2010derived dendritic cells and THP\u20101 cells to the prototypical contact sensitizer dinitrochlorobenzene potentiated the response of CD1a\u2010 and CD1d\u2010autoreactive T cells, which released a vast array of cytokines in a CD1\u2010 and TCR\u2010dependent manner. The potentiating effects of dinitrochlorobenzene depended upon newly synthesized CD1 molecules and the presence of endogenous stimulatory lipids. Further examination of a broad panel of contact sensitizers revealed 1,4\u2010benzoquinone, resorcinol, isoeugenol, and cinnamaldehyde to activate the same type of CD1\u2010restricted responses. These findings provide a basis for the antigen\u2010specific activation of skin\u2010associated CD1\u2010restricted T cells by small molecules and may have implications for contact sensitizer\u2010induced inflammatory skin diseases.<\/jats:p>","DOI":"10.1002\/eji.201746939","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T12:23:54Z","timestamp":1493123034000},"page":"1171-1180","source":"Crossref","is-referenced-by-count":33,"title":["Contact sensitizers trigger human CD1\u2010autoreactive T\u2010cell responses"],"prefix":"10.1002","volume":"47","author":[{"given":"Richard J.","family":"Betts","sequence":"first","affiliation":[{"name":"Singapore Immunology Network Agency for Science, Technology and Research  Singapore"},{"name":"L'Or\u00e9al Research &amp; Innovation Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrijana","family":"Perkovic","sequence":"additional","affiliation":[{"name":"Experimental 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