{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:38:43Z","timestamp":1791398323286,"version":"4.3.3"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent studies identified an emerging role of group 2 and 3 innate lymphoid cells (ILCs) as key players in the generation of T\u2010dependent and T\u2010independent antibody production. In this retrospective case\u2010control study, CD117<jats:sup>+<\/jats:sup> ILCs (including the majority of ILC2 and ILC3) were reduced in patients with common variable immunodeficiency (CVID). The reduction in CD117<jats:sup>+<\/jats:sup> ILCs was distinctive to CVID and could not be observed in patients with X\u2010linked agammaglobulinemia. Patients with a more pronounced reduction in CD117<jats:sup>+<\/jats:sup> ILC numbers showed significantly lower numbers of peripheral MZ\u2010like B\u00a0cells and an increased prevalence of chronic, non\u2010infectious enteropathy. Subsequent phenotyping of ILC subsets in CVID revealed that the reduction in CD117<jats:sup>+<\/jats:sup> ILC numbers is due to a reduction in ILC2 numbers. In vitro expansion of CVID ILC2 in response to IL\u20102, IL\u20107, IL\u201025 and IL\u201033 was impaired. Furthermore, upregulation of MHCII and IL\u20102RA in response to IL\u20102, IL\u20107, IL\u201025 and IL\u201033 was impaired in CVID ILC2. Thus, our results indicate a dysregulation of ILC subsets with a reduction in ILC2 numbers in CVID, however, further studies are needed to explore whether ILC abnormalities are a primary finding or secondary to disease complications encountered in CVID.<\/jats:p>","DOI":"10.1002\/eji.201746961","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T12:32:53Z","timestamp":1500381173000},"page":"1959-1969","source":"Crossref","is-referenced-by-count":17,"title":["Reduced numbers of circulating group 2 innate lymphoid cells in patients with common variable immunodeficiency"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4353-8663","authenticated-orcid":false,"given":"Christoph B.","family":"Geier","sequence":"first","affiliation":[{"name":"Immunology Outpatient Clinic  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Kraupp","sequence":"additional","affiliation":[{"name":"Immunology Outpatient Clinic  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bra","sequence":"additional","affiliation":[{"name":"Immunology Outpatient Clinic  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha M.","family":"Eibl","sequence":"additional","affiliation":[{"name":"Immunology Outpatient Clinic  Vienna Austria"},{"name":"Biomedizinische Forschungs GmbH  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn R.","family":"Farmer","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztian","family":"Csomos","sequence":"additional","affiliation":[{"name":"University of South Florida and Johns Hopkins All Children's Hospital  Saint Petersburg FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolan E.","family":"Walter","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Harvard Medical School  Boston MA USA"},{"name":"University of South Florida and Johns Hopkins All Children's Hospital  Saint Petersburg FL USA"},{"name":"Division of Immunology, Boston Children's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann M.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Immunology Outpatient Clinic  Vienna Austria"},{"name":"Sigmund Freud Private University\u2010 Medical School  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa6566"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","unstructured":"Hazenberg M. 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