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For large DNA viruses, these immune evasion mechanisms frequently rely on the expression of genes acquired from host genomes. Horizontally transferred genes include members of the immunoglobulin superfamily, whose products constitute the most diverse group of proteins of vertebrate genomes. Their promiscuous immunoglobulin domains, which comprise the building blocks of these molecules, are involved in a large variety of functions mediated by ligand\u2010binding interactions. The flexible structural nature of the immunoglobulin domains makes them appealing targets for viral capture due to their capacity to generate high functional diversity. Here, we present an up\u2010to\u2010date review of immunoglobulin superfamily gene homologs encoded by herpesviruses, poxviruses, and adenoviruses, that include CD200, CD47, Fc receptors, interleukin\u20101 receptor 2, interleukin\u201018 binding protein, CD80, carcinoembryonic antigen\u2010related cell adhesion molecules, and signaling lymphocyte activation molecules. We discuss their distinct structural attributes, binding properties, and functions, shaped by evolutionary pressures to disarm specific immune pathways. We include several novel genes identified from extensive genome database surveys. An understanding of the properties and modes of action of these viral proteins may guide the development of novel immune\u2010modulatory therapeutic tools.<\/jats:p>","DOI":"10.1002\/eji.201746984","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T11:51:29Z","timestamp":1491479489000},"page":"780-796","source":"Crossref","is-referenced-by-count":43,"title":["Immunoglobulin superfamily members encoded by viruses and their multiple roles in immune evasion"],"prefix":"10.1002","volume":"47","author":[{"given":"Dom\u00e8nec","family":"Farr\u00e9","sequence":"first","affiliation":[{"name":"Immunology Unit Department of Biomedical Sciences Medical School University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Mart\u00ednez\u2010Vicente","sequence":"additional","affiliation":[{"name":"Immunology Unit Department of Biomedical Sciences Medical School University of Barcelona  Barcelona 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