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However, the signaling mechanism leading from pSTAT3 to the expression of these genes remains unclear. We focused on Bcl\u20103, which is induced by STAT3 activation and mediates gene expression. In cultured human epidermal keratinocytes, IL\u201022 increased Bcl\u20103, which was translocated to the nucleus with p50 via STAT3 activation. The increases in CXCL8, S100As and human \u03b2\u2010defensin 2 mRNA expression caused by IL\u201022 were abolished by siRNA against Bcl\u20103. Although CCL20 expression was also augmented by IL\u201022, the knockdown of Bcl\u20103 increased its level. Moreover, the combination of IL\u201022 and IL\u201017A enhanced Bcl\u20103 production, IL\u201022\u2010induced gene expression, and the expression of other psoriasis\u2010related genes, including those encoding IL\u201017C, IL\u201019, and IL\u201036\u03b3. The expression of these genes (except for CCL20) was also suppressed by the knockdown of Bcl\u20103. Bcl\u20103 overexpression induced CXCL8 and HBD2 expression but not S100As expression. We also compared Bcl\u20103 expression between psoriatic skin lesions and normal skin. Immunostaining revealed strong signals for Bcl\u20103 and p50 in the nucleus of epidermal keratinocytes from psoriatic skin. The IL\u201022\u2010STAT3\u2010Bcl\u20103 pathway may be important in the pathogenesis of psoriasis.<\/jats:p>","DOI":"10.1002\/eji.201747017","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T02:30:53Z","timestamp":1505269853000},"page":"168-179","source":"Crossref","is-referenced-by-count":42,"title":["Bcl\u20103 induced by IL\u201022 via STAT3 activation acts as a potentiator of psoriasis\u2010related gene expression in epidermal keratinocytes"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4756-0155","authenticated-orcid":false,"given":"Mikiko","family":"Tohyama","sequence":"first","affiliation":[{"name":"Department of Dermatology Ehime University Graduate School of Medicine  Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Shirakata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ehime University Graduate School of Medicine  Ehime 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