{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:22:08Z","timestamp":1791501728722,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009729","name":"Ludwig Institute for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_152856"],"award-info":[{"award-number":["320030_152856"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["CRSII3_160708"],"award-info":[{"award-number":["CRSII3_160708"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004361","name":"Krebsliga Schweiz","doi-asserted-by":"publisher","award":["3507\u201008\u20102014"],"award-info":[{"award-number":["3507\u201008\u20102014"]}],"id":[{"id":"10.13039\/501100004361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The repertoire of human \u03b1\u03b2 T\u2010cell receptors (TCRs) is generated via somatic recombination of germline gene segments. Despite this enormous variation, certain epitopes can be immunodominant, associated with high frequencies of antigen\u2010specific T\u00a0cells and\/or exhibit bias toward a TCR gene segment. Here, we studied the TCR repertoire of the HLA\u2010A*0201\u2010restricted epitope LLWNGPMAV (hereafter, A2\/LLW) from Yellow Fever virus, which generates an immunodominant CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cell response to the highly effective YF\u201017D vaccine. We discover that these A2\/LLW\u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells are highly biased for the TCR \u03b1 chain TRAV12\u20102. This bias is already present in A2\/LLW\u2010specific na\u00efve T\u00a0cells before vaccination with YF\u201017D. Using CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cell clones, we show that TRAV12\u20102 does not confer a functional advantage on a per cell basis. Molecular modeling indicated that the germline\u2010encoded complementarity determining region (CDR) 1\u03b1 loop of TRAV12\u20102 critically contributes to A2\/LLW binding, in contrast to the conventional dominant dependence on somatically rearranged CDR3 loops. This germline component of antigen recognition may explain the unusually high precursor frequency, prevalence and immunodominance of T\u2010cell responses specific for the A2\/LLW epitope.\n                  <\/jats:p>","DOI":"10.1002\/eji.201747082","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:22:39Z","timestamp":1507076559000},"page":"258-272","source":"Crossref","is-referenced-by-count":44,"title":["T cell receptor alpha variable 12\u20102 bias in the immunodominant response to Yellow fever virus"],"prefix":"10.1002","volume":"48","author":[{"given":"Amandine","family":"Bovay","sequence":"first","affiliation":[{"name":"Department of Oncology Lausanne University Hospital (CHUV)  Epalinges Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Zoete","sequence":"additional","affiliation":[{"name":"SIB Swiss Institute of Bioinformatics Molecular Modeling Group  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry","family":"Dolton","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and Systems Immunity Research Institute Cardiff University School of Medicine  Heath Park Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Bulek","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and Systems Immunity Research Institute Cardiff University School of Medicine  Heath Park Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Cole","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and Systems Immunity Research Institute Cardiff University School of Medicine  Heath Park Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre J.","family":"Rizkallah","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and Systems Immunity Research Institute Cardiff University School of Medicine  Heath Park Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Fuller","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and Systems Immunity Research Institute Cardiff University School of Medicine  Heath Park Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Beck","sequence":"additional","affiliation":[{"name":"Cardiff University School of Dentistry  Heath Park Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Michielin","sequence":"additional","affiliation":[{"name":"SIB Swiss Institute of Bioinformatics Molecular Modeling Group  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Speiser","sequence":"additional","affiliation":[{"name":"Department of Oncology Lausanne University Hospital (CHUV)  Epalinges Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Sewell","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and Systems Immunity Research Institute Cardiff University School of Medicine  Heath Park Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3456-3317","authenticated-orcid":false,"given":"Silvia A.","family":"Fuertes Marraco","sequence":"additional","affiliation":[{"name":"Department of Oncology Lausanne University Hospital (CHUV)  Epalinges Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn838"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.31.082901.134423"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00517-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/384134a0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.022509"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112334"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2010.139"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa3700"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803903"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202234"},{"key":"e_1_2_7_12_1","first-page":"7","article-title":"T\u2010cell memory responses elicited by Yellow Fever vaccine are targeted to overlapping epitopes containing multiple HLA\u2010I and \u2010II binding motifs","author":"Melo A. 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