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Although this might induce the suspicion that PKC\u03b5 takes part in autoimmunity, its role in the molecular pathophysiology of immune\u2010mediated disorders is still largely unknown. We studied PKC\u03b5 expression in circulating CD4<jats:sup>+<\/jats:sup>\u2010T\u00a0cells from patients with psoriasis, a skin disorder characterized by an increased amount of Th17 cells, a CD4<jats:sup>+<\/jats:sup> subset that is critical in the development of autoimmunity. Although the mechanisms that underlie Th17 differentiation in humans are still unclear, we here show that: (i) PKC\u03b5 is overexpressed in CD4<jats:sup>+<\/jats:sup>\u2010T\u00a0cells from psoriatic patients, and its expression positively correlates with the severity of the disease, being reduced by effective phototherapy; (ii) PKC\u03b5 interacts with Stat3 during Th17 differentiation and its overexpression results in an enhanced expression of Stat3 and pStat3(Ser727); iii) conversely, when PKC\u03b5 is forcibly downregulated, CD4<jats:sup>+<\/jats:sup>\u2010T\u00a0cells show lower levels of pStat3(Ser727) expression and defective in vitro expansion into the Th17\u2010lineage. These data provide a novel insight into the molecular mechanisms of Th17 cell polarization that is known to play a crucial role in autoimmunity, pinpointing PKC\u03b5 as a potential target in Th17\u2010mediated diseases.<\/jats:p>","DOI":"10.1002\/eji.201747102","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T06:22:38Z","timestamp":1514355758000},"page":"644-654","source":"Crossref","is-referenced-by-count":13,"title":["PKC\u03b5\u00a0promotes human Th17 differentiation: Implications in the pathophysiology of psoriasis"],"prefix":"10.1002","volume":"48","author":[{"given":"Silvia","family":"Martini","sequence":"first","affiliation":[{"name":"Department of Medicine &amp; Surgery (DiMeC) University of Parma  Parma IT"},{"name":"CoreLab Azienda Ospedaliero\u2010Universitaria di Parma  Parma IT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Department of Medicine &amp; 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