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These responses are triggered upon T\u2010cell recognition of neo\u2010antigenic determinants, which are generated by a variety of environmental contact sensitizer (CS) chemicals associating with self\u2010proteins to comprise these neo\u2010antigens. In this issue of the <jats:italic>European Journal of Immunology<\/jats:italic>, Betts et\u00a0al. [<jats:italic>Eur. J. Immunol<\/jats:italic>. 2017. 47: 1171\u20131180] provide intriguing data implying that common small molecule CSs such as dinitrochlorobenzene can also recruit and activate autoreactive CD1\u2010restricted T cells specific for cell\u2010endogenous lipids, which are enriched in human skin. The effects of dinitrochlorobenzene on CD1 T\u2010cell recruitment and function were dependent on newly synthesized CD1 molecules and the presence of endogenous lipids. 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