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In C57BL\/6 mice (H\u20102<jats:sup>b<\/jats:sup>), the CTL response is mainly directed against epitopes from the LCMV glycoprotein (GP) and the nucleoprotein (NP) which represent the two major viral proteins. The role of GP\u2010 versus NP\u2010derived epitopes for viral clearance was examined using transgenic (tg) mice ubiquitously expressing LCMV GP and NP, respectively. These mice lack GP\u2010 or NP\u2010specific CTLs and show decreased levels of GP\u2010 or NP\u2010specific antibodies as a result of tolerance induction. During acute LCMV infection, CTLs specific for GP\u2010 and NP\u2010derived epitopes are generated with similar frequencies. Nonetheless, we found that lack of GP\u2010 but not of NP\u2010specific CTLs abolished control of acute LCMV infection. In contrast, after high\u2010dose or chronic LCMV infection, virus elimination was delayed to a similar extent in GP\u2010 and NP\u2010tg mice. Thus, immunological tolerance to LCMV antigens differently affects virus clearance in acute and chronic infection settings. In addition, our data reveal that immunodominance of H\u20102<jats:sup>b<\/jats:sup>\u2010restricted LCMV\u2010specific CTL epitopes and their antiviral activity do not strictly correlate.<\/jats:p>","DOI":"10.1002\/eji.201747156","type":"journal-article","created":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T02:22:42Z","timestamp":1502504562000},"page":"120-127","source":"Crossref","is-referenced-by-count":4,"title":["Immunological tolerance to LCMV antigens differently affects control of acute and chronic virus infection in mice"],"prefix":"10.1002","volume":"48","author":[{"given":"Christina","family":"Woopen","sequence":"first","affiliation":[{"name":"Institute for Immunology Medical Center University of Freiburg Faculty of Medicine University of Freiburg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Straub","sequence":"additional","affiliation":[{"name":"Institute for Immunology Medical Center University of Freiburg Faculty of Medicine University of Freiburg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Schweier","sequence":"additional","affiliation":[{"name":"Institute for Immunology Medical Center University of Freiburg Faculty of Medicine University of Freiburg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Aichele","sequence":"additional","affiliation":[{"name":"Institute for Immunology Medical Center University of Freiburg Faculty of Medicine University of Freiburg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"D\u00fcker","sequence":"additional","affiliation":[{"name":"Institute for Immunology Medical Center University of Freiburg Faculty of Medicine University of Freiburg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Boehm","sequence":"additional","affiliation":[{"name":"Department of Developmental Immunology Max Planck Institute of Immunobiology and Epigenetics  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-9589","authenticated-orcid":false,"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[{"name":"Institute for Immunology Medical Center University of Freiburg Faculty of Medicine University of Freiburg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01459-06"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.3.2124"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.10.5415"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.8.4911-4927.2003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.10.1647-b"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.5.3113"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.5.763"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000080"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"eeah6817","DOI":"10.1126\/sciimmunol.aah6817","article-title":"Interferon\u2010driven deletion of antiviral B cells at the onset of chronic infection","volume":"1","author":"Fallet B.","year":"2016","journal-title":"Sci. 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