{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:58:35Z","timestamp":1790416715597,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T00:00:00Z","timestamp":1525046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K11255"],"award-info":[{"award-number":["JP17K11255"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Unexpected fetal loss is one of the common complications of pregnancy; however, the pathogenesis of many miscarriages, particularly those not associated with infections, is unknown. We previously found that activated DEC\u2010205<jats:sup>+<\/jats:sup> dendritic cells (DCs) and NK1.1<jats:sup>+<\/jats:sup> invariant natural killer T (iNKT) cells are recruited into the myometrium of mice when miscarriage is induced by the intraperitoneal administration of \u03b1\u2010galactosylceramide (\u03b1\u2010GalCer). Here we demonstrate that the adoptive transfer of DEC\u2010205<jats:sup>+<\/jats:sup> bone marrow\u2010derived DCs cocultured with \u03b1\u2010GalCer (DEC\u2010205<jats:sup>+<\/jats:sup> BMDCs\u2010c\/w\u2010\u03b1\u2010GalCer) directly induced marked fetal loss by syngeneic pregnant C57BL\/6 (B6) mice and allogeneic mice (B6 (\u2640) \u00d7 BALB\/c (\u2642)), which was accompanied by the accumulation of activated iNKT cells in the myometrium. Further, the adoptive transfer of NK1.1<jats:sup>+<\/jats:sup> iNKT cells obtained from B6 mice injected with \u03b1\u2010GalCer facilitated miscarriages in syngeneic J\u03b118<jats:sup>(\u2212\/\u2212)<\/jats:sup> (iNKT cell\u2010deficient) mice. These results suggest that DEC\u2010205<jats:sup>+<\/jats:sup> DCs and NK1.1<jats:sup>+<\/jats:sup> iNKT cells play crucial roles required for the initiation of fetal loss associated with stimulation by glycolipid antigens and sterile inflammation.<\/jats:p>","DOI":"10.1002\/eji.201747162","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T06:52:41Z","timestamp":1520578361000},"page":"937-949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Miscarriage induced by adoptive transfer of dendritic cells and invariant natural killer T cells into mice"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4974-1574","authenticated-orcid":false,"given":"Yasuyuki","family":"Negishi","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Nippon Medical School  Tokyo Japan"},{"name":"Department of Obstetrics and Gynecology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-16-0453"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.041"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.73"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12443"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.740"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501962"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.14.5248"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.10.5690"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12266"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2007.00511.x"},{"key":"e_1_2_7_13_1","first-page":"3954","article-title":"Uterine DCs are crucial for decidua formation during embryo implantation in mice","volume":"118","author":"Plaks V.","year":"2008","journal-title":"J. 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