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However, the cellular response of the nasopharyngeal compartment to pneumococcal colonization and its importance for the ensuing adaptive immune response is only partially defined. Here we show that nasopharyngeal colonization with <jats:italic>S.\u00a0pneumoniae<\/jats:italic> triggered substantial expansion of both integrin \u03b1E (CD103) positive dendritic cells (DC) and T lymphocytes in nasopharynx, nasal\u2010associated lymphoid tissue (NALT) and cervical lymph nodes (CLN) of WT mice. However, nasopharyngeal de\u2010colonization and pneumococcus\u2010specific antibody responses were similar between WT and CD103 KO mice or Batf3 KO mice. Also, na\u00efve WT mice passively immunized with antiserum from previously colonized WT and CD103\u00a0KO mice were similarly protected against invasive pneumococcal disease (IPD). In summary, the data show that CD103 is dispensable for pneumococcal colonization\u2010induced adaptive immune responses in mice.<\/jats:p>","DOI":"10.1002\/eji.201747236","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T17:23:33Z","timestamp":1521134613000},"page":"965-974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Colonization\u2010induced protection against invasive pneumococcal disease in mice is independent of CD103 driven adaptive immune responses"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8104-8131","authenticated-orcid":false,"given":"Anne","family":"Dommaschk","sequence":"first","affiliation":[{"name":"Department of Experimental Pneumology Hannover School of Medicine  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara 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