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Previous work has shown that IgM also binds within the glomerulus after ischemia\/reperfusion (I\/R) but does not fully activate the complement system. Factor H is a circulating complement regulatory protein, and congenital or acquired deficiency of factor H is a strong risk factor for several types of kidney disease. We hypothesized that factor H controls complement activation by IgM in the kidney after I\/R, and that heterozygous factor H deficiency would permit IgM\u2010mediated complement activation and injury at this location. We found that mice with targeted heterozygous deletion of the gene for factor H developed more severe kidney injury after I\/R than wild\u2010type controls, as expected, but that complement activation within the glomeruli remained well controlled. Furthermore, mice that are unable to generate soluble IgM were not protected from renal I\/R, even in the setting of heterozygous factor H deficiency. These results demonstrate that factor H is important for limiting injury in the kidney after I\/R, but it is not critical for controlling complement activation by immunoglobulin within the glomerulus in this setting. IgM binds to glomerular epitopes after I\/R, but it is not a significant source of injury.<\/jats:p>","DOI":"10.1002\/eji.201747240","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T16:52:45Z","timestamp":1517503965000},"page":"791-802","source":"Crossref","is-referenced-by-count":19,"title":["Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM"],"prefix":"10.1002","volume":"48","author":[{"given":"Lindsey","family":"Goetz","sequence":"first","affiliation":[{"name":"Department of Medicine University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Laskowski","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Renner","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew C.","family":"Pickering","sequence":"additional","affiliation":[{"name":"Centre for Complement &amp; Inflammation Research Imperial College  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liudmila","family":"Kulik","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Klawitter","sequence":"additional","affiliation":[{"name":"Department of Anesthesia University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Stites","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Christians","sequence":"additional","affiliation":[{"name":"Department of Anesthesia University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"van der Vlag","sequence":"additional","affiliation":[{"name":"Department of Nephrology Radboud Institute for Molecular Life Sciences Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kameswaran","family":"Ravichandran","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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