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By sequencing the complementary determining region 3 of T\u2010cell receptor (TCR) \u03b2 chains from the purified antigen\u2010experienced CD8<jats:sup>+<\/jats:sup> T\u00a0cells, we characterized the T\u2010cell repertoire in a prospective cohort study among 75 patients with chronic hepatitis B in China, as well as a healthy control and a validation cohort. We found that most T\u2010cell clones from patients harbored the \u201cpatient\u2010specific\u201d TCR sequences. However, \u201cpatient\u2010shared\u201d TCR clonotypes were also widely found, which correlated with the favorable turnover of disease. Interestingly, the frequency of the \u201cpatient\u2010shared\u201d clonotypes can serve as a biomarker for favorable prognosis. Based on the clonotypes in those patients with favorable outcomes, we created a database including several clusters of protective anti\u2010HBV CD8<jats:sup>+<\/jats:sup> T\u2010cell clonotypes that might be a reasonable target for therapeutic vaccine development or adoptive cell transfer therapy. These findings were validated in an additional independent cohort of patients. These results suggest that the \u201cpatient\u2010shared\u201d TCR clonotypes may serve as a valuable prognostic tool in the treatment of chronic hepatitis B and possibly other chronic viral diseases.<\/jats:p>","DOI":"10.1002\/eji.201747327","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T14:24:41Z","timestamp":1527863081000},"page":"1539-1549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Patient\u2010shared TCR\u03b2\u2010CDR3 clonotypes correlate with favorable prognosis in chronic hepatitis B"],"prefix":"10.1002","volume":"48","author":[{"given":"Qiong","family":"Jiang","sequence":"first","affiliation":[{"name":"Institute of Immunology PLA Third Military Medical University  Chongqing P. R. 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