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Here, we demonstrated asthmatic features in both primary bronchial epithelial cells (pBECs) and mouse model using several allergens including ovalbumin (OVA), house dust mite (HDM), or <jats:italic>Alternaria alternata<\/jats:italic>. We found that toll\u2010like receptor 2 (TLR2) was highly induced in ECs but not dendritic cells (DCs) by various allergens, leading to recruitment of circulating basophils into the lung via C\u2010C chemokine ligand\u20102 (CCL2). TLR2 expression increased thymic stromal lymphopoietin (TSLP) production through the NF\u2010\u03baB and JNK signaling pathways to extend the survival of recruited basophils and resident DCs in the lung, predisposing a type\u20102\u2010cell\u2010mediated airway inflammation. Conversely, TLR2 deficiency impaired <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/secretion\">secretion<\/jats:ext-link> of TSLP and CCL2, decreased infiltration of lung basophils, and increased resistance to Th2 response. Blocking TSLP also phenocopied these phenomena. Our findings reveal a pro\u2010inflammatory role of airway ECs through a TLR2\u2010dependent TSLP production, which may have implication for treating allergic asthma.<\/jats:p>","DOI":"10.1002\/eji.201847663","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T14:44:39Z","timestamp":1536158679000},"page":"1838-1850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Airway epithelial TSLP production of TLR2 drives type 2 immunity in allergic airway inflammation"],"prefix":"10.1002","volume":"48","author":[{"given":"Jiajia","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianying","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ruijin Hospital affiliated 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