{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T06:18:34Z","timestamp":1785565114016,"version":"3.56.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T00:00:00Z","timestamp":1549238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1160\/P3"],"award-info":[{"award-number":["SFB 1160\/P3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Infection of C57BL\/6 mice with lymphocytic choriomeningitis virus (LCMV) strain Armstrong (Arm) induces an acute infection with rapid virus clearance by CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells independently of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cell help. Residual viral antigen may, however, persist for a prolonged time. Here, we demonstrate that mice that had been transiently depleted of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells during acute LCMV Arm infection generated high levels of virus\u2010specific IgG antibodies (Ab) after viral clearance. Robust induction of LCMV\u2010specific IgG after transient CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cell depletion was dependent on Fc\u03b3 receptors but not on the complement receptors CD21\/CD35. In contrast to the potent production of LCMV\u2010specific IgG, the generation of LCMV\u2010specific isotype\u2010switched memory B\u00a0cells after transient CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cell depletion was considerably reduced. Moreover, mice depleted of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells during acute infection were strongly impaired in generating a secondary LCMV\u2010specific B\u00a0cell response upon LCMV rechallenge. In conclusion, our data indicate that LCMV antigen depots after viral clearance were capable of inducing high levels of virus\u2010specific IgG. They failed, however, to induce robust virus\u2010specific B\u00a0cell memory revealing a previously unappreciated dichotomy of specific Ab production and memory cell formation after priming with residual antigen.\n                  <\/jats:p>","DOI":"10.1002\/eji.201847772","type":"journal-article","created":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T09:09:07Z","timestamp":1547284147000},"page":"626-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Residual LCMV antigen in transiently CD4\n                    <sup>+<\/sup>\n                    T\u00a0cell\u2010depleted mice induces high levels of virus\u2010specific antibodies but only limited B\u2010cell memory"],"prefix":"10.1002","volume":"49","author":[{"given":"Oliver","family":"Schweier","sequence":"first","affiliation":[{"name":"Institute for Immunology Medical Center \u2010 University of Freiburg Faculty of Medicine University of Freiburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Aichele","sequence":"additional","affiliation":[{"name":"Institute for Immunology Medical Center \u2010 University of Freiburg Faculty of Medicine University of Freiburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Friederike","family":"Marx","sequence":"additional","affiliation":[{"name":"Institute for Immunology Medical Center \u2010 University of Freiburg Faculty of Medicine University of Freiburg  Germany"},{"name":"Division of Experimental Virology Department of Biomedicine University of Basel  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Straub","sequence":"additional","affiliation":[{"name":"Institute for Immunology Medical Center \u2010 University of Freiburg Faculty of Medicine University of Freiburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Sjef","family":"Verbeek","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Pinschewer","sequence":"additional","affiliation":[{"name":"Division of Experimental Virology Department of Biomedicine University of Basel  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-9589","authenticated-orcid":false,"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[{"name":"Institute for Immunology Medical Center \u2010 University of Freiburg Faculty of Medicine University of Freiburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182189999"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.6.3095"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00081-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050227"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.01.015"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092017"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02167-06"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301215"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1128\/jvi.62.6.2102-2106.1988","article-title":"T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T\u2010cell and antibody responses","volume":"62","author":"Ahmed R.","year":"1988","journal-title":"J. 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