{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:30:51Z","timestamp":1790184651406,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003134","name":"Fonds pour la Formation \u00e0 la Recherche dans l\u2019Industrie et dans l\u2019Agriculture","doi-asserted-by":"publisher","award":["FRIA 1.E113.15"],"award-info":[{"award-number":["FRIA 1.E113.15"]}],"id":[{"id":"10.13039\/501100003134","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005627","name":"Universit\u00e9 de Li\u00e8ge","doi-asserted-by":"publisher","award":["grant n\u00b0FSRC\u201015\/03"],"award-info":[{"award-number":["grant n\u00b0FSRC\u201015\/03"]}],"id":[{"id":"10.13039\/501100005627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alternatively activated M\u03c6s (AAM\u03c6) accumulate in hepatic granulomas during schistosomiasis and have been suggested to originate in the bone marrow. What is less understood is how these M\u03c6 responses are regulated after\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    infection. Here, we investigated the role of IL\u20104 receptor \u03b1\u2010chain (IL\u20104R\u03b1)\u2010signalling in the dynamics of liver M\u03c6 responses. We observed that IL\u20104R\u03b1 signalling was dispensable for the recruitment of Ly6C\n                    <jats:sup>hi<\/jats:sup>\n                    monocytes and for their conversion into F4\/80\n                    <jats:sup>hi<\/jats:sup>\n                    CD64\n                    <jats:sup>hi<\/jats:sup>\n                    CD11b\n                    <jats:sup>hi<\/jats:sup>\n                    M\u03c6. Moreover, while IL\u20104R\u03b1 provided an AAM\u03c6 phenotype to liver F4\/80\n                    <jats:sup>hi<\/jats:sup>\n                    CD64\n                    <jats:sup>hi<\/jats:sup>\n                    CD11b\n                    <jats:sup>hi<\/jats:sup>\n                    M\u03c6 that was associated with regulation of granuloma formation, it was dispensable for host survival. Resident F4\/80\n                    <jats:sup>hi<\/jats:sup>\n                    CD64\n                    <jats:sup>hi<\/jats:sup>\n                    CD11b\n                    <jats:sup>lo<\/jats:sup>\n                    M\u03c6 did not upregulate the AAM\u03c6 signature gene Ym1. Rather, resident M\u03c6 nearly disappeared by week 8 after infection and artificial ablation of resident M\u03c6 in CD169\n                    <jats:sup>DTR<\/jats:sup>\n                    mice did not affect the response to\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    infection. Interestingly, ablation of CD169\n                    <jats:sup>+<\/jats:sup>\n                    cells in naive mice resulted in the accumulation of F4\/80\n                    <jats:sup>hi<\/jats:sup>\n                    CD64\n                    <jats:sup>hi<\/jats:sup>\n                    CD11b\n                    <jats:sup>hi<\/jats:sup>\n                    M\u03c6, which was amplified when ablation occurred during schistosomiasis. Altogether, our results suggest the ablation of resident KCs after\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    infection to be associated with the recruitment and accumulation of F4\/80\n                    <jats:sup>hi<\/jats:sup>\n                    CD64\n                    <jats:sup>hi<\/jats:sup>\n                    CD11b\n                    <jats:sup>hi<\/jats:sup>\n                    M\u03c6 with\n                    <jats:italic>lyz2<\/jats:italic>\n                    \u2010dependent IL\u20104R\u03b1 contributing to the regulation of granuloma inflammation but being dispensable for host survival.\n                  <\/jats:p>","DOI":"10.1002\/eji.201847796","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T06:42:34Z","timestamp":1553755354000},"page":"1067-1081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Recruitment of hepatic macrophages from monocytes is independent of IL\u20104R\u03b1 but is associated with ablation of resident macrophages in schistosomiasis"],"prefix":"10.1002","volume":"49","author":[{"given":"Marion","family":"Rolot","sequence":"first","affiliation":[{"name":"Immunology\u2010Vaccinology Department of Infectious and Parasitic Diseases Faculty of Veterinary Medicine \u2013 FARAH University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette M.","family":"Dougall","sequence":"additional","affiliation":[{"name":"Immunology\u2010Vaccinology Department of Infectious and Parasitic Diseases Faculty of Veterinary Medicine \u2013 FARAH University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Javaux","sequence":"additional","affiliation":[{"name":"Immunology\u2010Vaccinology Department of Infectious and Parasitic Diseases Faculty of Veterinary Medicine \u2013 FARAH University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Lallemand","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy University Hospital Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Machiels","sequence":"additional","affiliation":[{"name":"Immunology\u2010Vaccinology Department of Infectious and Parasitic Diseases Faculty of Veterinary Medicine \u2013 FARAH University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Martinive","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy University Hospital Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Gillet","sequence":"additional","affiliation":[{"name":"Immunology\u2010Vaccinology Department of Infectious and Parasitic Diseases Faculty of Veterinary Medicine \u2013 FARAH University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-0799","authenticated-orcid":false,"given":"Benjamin G.","family":"Dewals","sequence":"additional","affiliation":[{"name":"Immunology\u2010Vaccinology Department of Infectious and Parasitic Diseases Faculty of Veterinary Medicine \u2013 FARAH University of Li\u00e8ge  Li\u00e8ge 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