{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T01:21:31Z","timestamp":1776302491493,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T00:00:00Z","timestamp":1549843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DE 485\/10\u20101\/HU 295\/9\u20101"],"award-info":[{"award-number":["DE 485\/10\u20101\/HU 295\/9\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Increasing evidence suggests a role of CD8 T\u00a0cells in autoimmune demyelinating CNS disease, which, however, is still controversially discussed. Mice, which express ovalbumin (OVA) as cytosolic self\u2010antigen in oligodendrocytes (ODC\u2010OVA mice), respond to CNS infection induced by OVA\u2010expressing attenuated\n                    <jats:italic>Listeria<\/jats:italic>\n                    with CD8 T\u00a0cell\u2010mediated inflammatory demyelination. This model is suitable to decipher the contribution of CD8 T\u00a0cells and the pathogen in autoimmune CNS disease.\n                  <\/jats:p>\n                  <jats:p>Here, we show that both antigen and pathogen are required in the CNS for disease induction, though not in a physically linked fashion. Intracerebral challenge with combined toll like receptor (TLR) TLR2 and TLR9 as well as TLR7 and TLR9 agonists substituted for the bacterial stimulus, but not with individual TLR agonists (TLR2, TLR3,TLR5,TLR7, TLR9). Furthermore, MyD88 inactivation rendered ODC\u2010OVA mice resistant to disease induction.<\/jats:p>\n                  <jats:p>Collectively, CD8 T\u00a0cell\u2010mediated destruction of oligodendrocytes is activated if (i) an antigen shared with an infectious agent is provided in the CNS microenvironment and (ii) innate immune signals inform the CNS microenvironment that pathogen removal warrants an immune attack by CD8 T\u00a0cells, even at the expense of locally restricted demyelination.<\/jats:p>","DOI":"10.1002\/eji.201847834","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T07:37:23Z","timestamp":1548229043000},"page":"413-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["TLR signals license CD8 T\u00a0cells to destroy oligodendrocytes expressing an antigen shared with a\n                    <i>Listeria<\/i>\n                    pathogen"],"prefix":"10.1002","volume":"49","author":[{"given":"Monica","family":"S\u00e1nchez\u2010Ruiz","sequence":"first","affiliation":[{"name":"Department of Neuropathology Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelle Katherine","family":"Polakos","sequence":"additional","affiliation":[{"name":"Institute for Virology and Immunobiology University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Blau","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Uterm\u00f6hlen","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology Immunology, and Hygiene, Medical Center University of Cologne  Cologne Germany"},{"name":"Center for Molecular Medicine Cologne (CMMC) University of Cologne  Cologne Germany"},{"name":"German Center for Infection Research (DZIF) Partner Site Bonn\u2010Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Brunn","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Montesinos\u2010Rongen","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0401-1711","authenticated-orcid":false,"given":"Thomas","family":"H\u00fcnig","sequence":"additional","affiliation":[{"name":"Institute for Virology and Immunobiology University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2468-0608","authenticated-orcid":false,"given":"Martina","family":"Deckert","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00064.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.04.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17935"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000170"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300452"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.09.011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00619"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102186"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.5.669"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1888"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7579"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1631-4"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.3.393"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(83)90201-0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240408"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf059"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00064"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2017.02.012"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-012-0077-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.12.8421"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22767"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535211"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn148"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.04.009"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.11.1013"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110164"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045860"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.01.006"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242985"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26078"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737187"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00404-X"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-5-154"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199601000-00002"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00046-08"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20952"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.04.011"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830250839"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01771-8"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-014-0166-7"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200526024"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90169-4"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.05.016"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050660"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060507"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646632"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.071101"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201847834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201847834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eji.201847834","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201847834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T14:19:19Z","timestamp":1694269159000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201847834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,11]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/eji.201847834"],"URL":"https:\/\/doi.org\/10.1002\/eji.201847834","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/EJI.201847834\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.201847834\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.201847834\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.201847834\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.201847834\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.201847834\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.201847834\/v2\/review2","asserted-by":"object"}]},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,11]]},"assertion":[{"value":"2018-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}