{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:05:54Z","timestamp":1772118354926,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The helminth\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    (\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    ) induces a network of regulatory immune cells, including interleukin (IL)\u201010\u2010producing regulatory B cells (Bregs). However, the signals required for the development and activation of Bregs are not well characterized. Recent reports suggest that helminths induce type I interferons (IFN\u2010I), and that IFN\u2010I drive the development of Bregs in humans. We therefore assessed the role of IFN\u2010I in the induction of Bregs by\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    . Mice chronically infected with\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    or i.v. injected with\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    soluble egg antigen (SEA) developed a systemic IFN\u2010I signature. Recombinant IFN\u2010\u03b1 enhanced IL\u201010 production by Bregs stimulated with\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    SEA in vitro, while not activating Bregs by itself. IFN\u2010I signaling also supported ex vivo IL\u201010 production by SEA\u2010primed Bregs but was dispensable for activation of\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    egg\u2010induced Bregs in vivo. These data indicate that although IFN\u2010I can serve as a coactivator for Breg IL\u201010 production, they are unlikely to participate in the development of Bregs in response to\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    eggs.\n                  <\/jats:p>","DOI":"10.1002\/eji.201847858","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T09:24:48Z","timestamp":1558085088000},"page":"1226-1234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Type I interferons provide additive signals for murine regulatory B cell induction by\n                    <i>Schistosoma mansoni<\/i>\n                    eggs"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5617-2029","authenticated-orcid":false,"given":"Katja","family":"Obieglo","sequence":"first","affiliation":[{"name":"Department of Parasitology Leiden 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