{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:08:20Z","timestamp":1772118500879,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:00:00Z","timestamp":1565136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    CD200 receptor 1(CD200R1) signalling limits myeloid cell responses and reduces autoimmunity, alloimmunity and viral\u2010mediated immunopathology, but has never been examined in the context of eosinophilic inflammation. Susceptibility to lung fungal infection is associated with T\u2010helper 2 (Th2) cytokine dominated responses and strong eosinophilic pathology. Blockade of CD200R1 enhances type I cytokine responses in many infectious and non\u2010infectious settings and so may promote a more protective response to fungal infection. By contrast, we demonstrate that, rather than promoting type I cytokine responses, CD200R1 blockade enhanced eosinophilia in a mouse model of\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    infection, whereas CD200R1 agonism reduced lung eosinophilia \u2013 with neither strategy completely altering fungal burden. Thus, we reveal a surprising disconnect between pulmonary eosinophilia and cryptococcal burden and dissemination. This research has 2 important implications. Firstly, a lack of CD200R1 signalling enhances immune responses regardless of cytokine polarisation, and secondly reducing eosinophils does not allow protective immunity to develop in susceptible fungal system. Therefore, agonists of CD200R1 may be beneficial for eosinophilic pathologies.\n                  <\/jats:p>","DOI":"10.1002\/eji.201847861","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T09:14:27Z","timestamp":1564564467000},"page":"1380-1390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["CD200R1 regulates eosinophilia during pulmonary fungal infection in mice"],"prefix":"10.1002","volume":"49","author":[{"given":"Samira","family":"Salek\u2010Ardakani","sequence":"first","affiliation":[{"name":"National Heart and Lung Institute, Department of Inflammation Development &amp; Repair, Imperial College London  UK"},{"name":"Manchester Collaborative Centre for Inflammation Research (MCCIR)  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bell","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Department of Inflammation Development &amp; Repair, Imperial College London  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P","family":"Jagger","sequence":"additional","affiliation":[{"name":"Manchester Collaborative Centre for Inflammation Research (MCCIR)  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J","family":"Snelgrove","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Department of Inflammation Development &amp; Repair, Imperial College London  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Hussell","sequence":"additional","affiliation":[{"name":"Manchester Collaborative Centre for Inflammation Research (MCCIR)  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)02223-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5497.1768"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2002.5232"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070272"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200206270-00018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/83124"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3600"},{"key":"e_1_2_7_9_1","first-page":"1074","article-title":"A critical function for CD200 in lung immune homeostasis and the severity of influenza infection","volume":"9","author":"Snelgrove R. 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