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The monoglycosylated diacylglycerol known as\n                    <jats:italic>B. burgdorferi glycolipid II<\/jats:italic>\n                    (BbGL\u2010II) is a major target of antibodies in sera from infected individuals. Here, we show that CD1b presents BbGL\u2010II to human T cells and that the TCR mediates the recognition. However, we did not detect increased frequency of CD1b\u2010BbGL\u2010II binding T cells in the peripheral blood of Lyme disease patients compared to controls. Unexpectedly, mapping the T cell specificity for BbGL\u2010II\u2010like molecules using tetramers and activation assays revealed a concomitant response to CD1b\u2010expressing APCs in absence of BbGL\u2010II. Further, among all major classes of self\u2010lipid tested, BbGL\u2010II responsive TCRs show strong cross\u2010reactivity to diacylglycerol, a self\u2010lipid antigen with structural similarities to BbGL\u2010II. Extending prior work on MHC and CD1b, CD1c, and CD1d proteins, this study provides evidence for cross\u2010reactive CD1b\u2010restricted T cell responses to bacterial and self\u2010antigens, and identifies chemically defined targets for future discovery of self and foreign antigen cross\u2010reactive T cells.\n                  <\/jats:p>","DOI":"10.1002\/eji.201847949","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T02:56:21Z","timestamp":1552272981000},"page":"737-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["CD1b presents self and\n                    <i>Borrelia burgdorferi<\/i>\n                    diacylglycerols to human T cells"],"prefix":"10.1002","volume":"49","author":[{"given":"Peter","family":"Reinink","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Immunology Faculty of Veterinary Medicine Utrecht University  Utrecht The Netherlands"},{"name":"Brigham and Women's Hospital Division of Rheumatology Immunology and Allergy, Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N. 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