{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:56:30Z","timestamp":1777532190736,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001656","name":"Helmholtz-Gemeinschaft","doi-asserted-by":"publisher","award":["VH\u2010GS\u2010202"],"award-info":[{"award-number":["VH\u2010GS\u2010202"]}],"id":[{"id":"10.13039\/501100001656","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHM1586\/6\u20101"],"award-info":[{"award-number":["SCHM1586\/6\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB854 (Project A23)"],"award-info":[{"award-number":["SFB854 (Project A23)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acquisition of effector functions in T\u00a0cells is guided by transcription factors, including NF\u2010\u03baB, that itself is tightly controlled by inhibitory proteins. The atypical NF\u2010\u03baB inhibitor, I\u03baB\n                    <jats:sub>NS,<\/jats:sub>\n                    is involved in the development of Th1, Th17, and regulatory T (Treg) cells. However, it remained unclear to which extend I\u03baB\n                    <jats:sub>NS<\/jats:sub>\n                    contributed to the acquisition of effector function in T\u00a0cells specifically responding to a pathogen during in vivo infection. Tracking of adoptively transferred T\u00a0cells in\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    infected mice antigen\u2010specific activation of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells following in vivo pathogen encounter to strongly rely on I\u03baB\n                    <jats:sub>NS<\/jats:sub>\n                    . While I\u03baB\n                    <jats:sub>NS<\/jats:sub>\n                    was largely dispensable for the acquisition of cytotoxic effector function in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells, I\u03baB\n                    <jats:sub>NS<\/jats:sub>\n                    \u2010deficient Th1 effector cells exhibited significantly reduced proliferation, marked changes in the pattern of activation marker expression, and reduced production of the Th1\u2010cell cytokines IFN\u2010\u03b3, IL\u20102, and TNF\u2010\u03b1. Complementary in vitro analyses using cells from novel reporter and inducible knockout mice revealed that I\u03baB\n                    <jats:sub>NS<\/jats:sub>\n                    predominantly affects the early phase of Th1\u2010cell differentiation while its function in terminally differentiated cells appears to be negligible. Our data suggest I\u03baB\n                    <jats:sub>NS<\/jats:sub>\n                    as a potential target to modulate specifically CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell responses.\n                  <\/jats:p>","DOI":"10.1002\/eji.201847961","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T07:47:27Z","timestamp":1556869647000},"page":"1391-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Essential role of I\u03baB\n                    <sub>NS<\/sub>\n                    for in vivo CD4\n                    <sup>+<\/sup>\n                    T\u2010cell activation, proliferation, and Th1\u2010cell differentiation during\n                    <i>Listeria monocytogenes<\/i>\n                    infection in mice"],"prefix":"10.1002","volume":"49","author":[{"given":"Sarah","family":"Frentzel","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, Infection Prevention and Control, Infection Immunology Group, Health Campus Immunology, Infectiology and Inflammation Otto\u2010von\u2010Guericke University Magdeburg  Magdeburg Germany"},{"name":"Immune Regulation Group Helmholtz Centre for Infection Research  Braunschweig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Katsoulis\u2010Dimitriou","sequence":"additional","affiliation":[{"name":"Systems\u2010oriented Immunology and Inflammation Research Group Helmholtz Centre for Infection Research  Braunschweig Germany"},{"name":"Institute for Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation Otto\u2010von\u2010Guericke University Magdeburg  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Jeron","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Infection Prevention and Control, Infection Immunology Group, Health Campus Immunology, Infectiology and Inflammation Otto\u2010von\u2010Guericke University Magdeburg  Magdeburg Germany"},{"name":"Immune Regulation Group Helmholtz Centre for Infection Research  Braunschweig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5360-0419","authenticated-orcid":false,"given":"Ingo","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Systems\u2010oriented Immunology and Inflammation Research Group Helmholtz Centre for Infection Research  Braunschweig Germany"},{"name":"Institute for Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation Otto\u2010von\u2010Guericke University Magdeburg  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3066-189X","authenticated-orcid":false,"given":"Dunja","family":"Bruder","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Infection Prevention and Control, Infection Immunology Group, Health Campus Immunology, Infectiology and Inflammation Otto\u2010von\u2010Guericke University Magdeburg  Magdeburg Germany"},{"name":"Immune Regulation Group Helmholtz Centre for Infection Research  Braunschweig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.183434.111"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-11-23"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.4049\/jimmunol.163.9.5116","article-title":"Preferential role for NF\u2010kappa B\/Rel signaling in the type 1 but not type 2 T\u00a0cell\u2010dependent immune response in vivo","volume":"163","author":"Aronica M. A.","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.4.1816"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80291-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.2.187"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.2A0814-384R"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511956200"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15252"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202717"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.08.042"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00469-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.3.1681"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.023"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401964"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.11.004"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80702-3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02738"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4432"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.771667"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203057"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxu092"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.6.4109"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110838"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2015.09.020"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2000.00889.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.9.4706"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05541"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646632"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43985"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600877"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201847961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201847961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eji.201847961","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201847961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T19:04:47Z","timestamp":1694027087000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201847961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,7]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/eji.201847961"],"URL":"https:\/\/doi.org\/10.1002\/eji.201847961","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/EJI.201847961\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.201847961\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.201847961\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.201847961\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.201847961\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.201847961\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.201847961\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,7]]},"assertion":[{"value":"2018-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}