{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:32:58Z","timestamp":1775521978631,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB\u00a01160;\u00a0P3"],"award-info":[{"award-number":["SFB\u00a01160;\u00a0P3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hyper\u2010activated or deviated immune responses can result in immunopathological diseases. Paradoxically, immunodeficiency represents a frequent cause of such immune\u2010mediated pathologies. Immunopathological manifestations are commonly treated by immunosuppression, but in situations in which immunodeficiency is the basis of disease development, enhancing immunity may represent an alternative treatment option. Here, we tested this counterintuitive concept in a preclinical model using infection of mice with lymphocytic choriomeningitis virus (LCMV). Firstly, we demonstrate that infection of B\u2010cell\u2010deficient (B\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) but not of wild\u2010type (WT) mice with the LCMV strain Docile induced a rapid and fatal CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell\u2010mediated immunopathological disease. Similar to WT mice, LCMV\u2010infected B\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice generated a potent, functional LCMV\u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell response but exhibited prolonged viral antigen presentation and increased vascular leakage in liver and lungs. Secondly, we were able to prevent this virus\u2010induced immunopathology in B\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice by active or passive T\u2010cell immunizations or by treatment with LCMV\u2010specific virus neutralizing or non\u2010neutralizing monoclonal antibodies (mAb). Thus, boosting antiviral immunity did not aggravate immunopathology in this model, but prevented it by decreasing the formation of target structures for damage\u2010causing CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells.\n                  <\/jats:p>","DOI":"10.1002\/eji.201847962","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T08:26:20Z","timestamp":1550823980000},"page":"782-789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Enhancing immunity prevents virus\u2010induced T\u2010cell\u2010mediated immunopathology in B cell\u2010deficient mice"],"prefix":"10.1002","volume":"49","author":[{"given":"Tobias","family":"Straub","sequence":"first","affiliation":[{"name":"Institute for Immunology, Medical Center \u2010 University of Freiburg Faculty of Medicine, University of Freiburg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-9589","authenticated-orcid":false,"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Medical Center \u2010 University of Freiburg Faculty of Medicine, University of Freiburg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000218"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300620"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3251"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343565"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121015"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1408148111"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804674115"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000080"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343566"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.6.3620"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830271023"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.5.3266"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.5.2165"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260943"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/362758a0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90644-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830230834"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(91)90018-U"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2104"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005276"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(83)90135-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646632"}],"container-title":["European 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