{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:05:55Z","timestamp":1772118355104,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Besides fatigue, many Q fever fatigue syndrome (QFS) patients also complain of frequently recurring upper respiratory tract infections with severe symptoms. We investigated whether immunologic dysregulation contributes to these complaints. Cytokine and chemokine production was measured after stimulating monocytes of QFS patients and age\u2010 and sex\u2010matched healthy controls with LPS and several viral ligands. The H3K4me3 mark of open chromatin was measured at the promoter regions of cytokines and chemokines that differed significantly from healthy controls. Monocytes of QFS patients produced significantly less TNF\u2010\u03b1 (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.032), IL\u20101\u03b2 (0.004, 0.024, and 0.008), IL\u20106 (0.043), RANTES (0.033), IP\u201010 (0.049), MCP\u20101 (0.022), IL\u2010 13 (0.029), and IL\u201010 (0.026) than healthy controls when stimulated with various ligands. H3K4me3 expression was significantly lower in QFS patients than in healthy controls on the promoter regions of IL\u20101\u03b2 (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.004), MCP\u20101 (&lt;0.001 and &lt;0.001), IP\u201010 (&lt;0.001), IL\u201010 (0.041), and IL\u201013 (&lt;0.001, &lt;0.001, and 0.001). QFS patients showed diminished cytokine responses to various stimuli compared to age\u2010 and sex\u2010matched healthy controls, likely due to epigenetic remodeling and long\u2010term memory as a result from the acute Q fever infection. This might explain the upper respiratory tract ailments in QFS.\n                  <\/jats:p>","DOI":"10.1002\/eji.201848012","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T02:13:46Z","timestamp":1555640026000},"page":"1015-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A possible link between recurrent upper respiratory tract infections and lower cytokine production in patients with Q fever fatigue syndrome"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0665-6022","authenticated-orcid":false,"given":"Ruud P.H.","family":"Raijmakers","sequence":"first","affiliation":[{"name":"Radboud Expertise Center for Q fever Department of Internal Medicine Division of Infectious Diseases Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Department of Internal Medicine Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne F.M.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Radboud Expertise Center for Q fever Department of Internal Medicine Division of Infectious Diseases Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Department of Internal Medicine Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan P.","family":"Keijmel","sequence":"additional","affiliation":[{"name":"Radboud Expertise Center for Q fever Department of Internal Medicine Division of Infectious Diseases Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Department of Internal Medicine Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos W.M.","family":"van der Meer","sequence":"additional","affiliation":[{"name":"Radboud Expertise Center for Q fever Department of Internal Medicine Division of Infectious Diseases Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Department of Internal Medicine Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo A.B.","family":"Joosten","sequence":"additional","affiliation":[{"name":"Radboud Expertise Center for Q fever Department of Internal Medicine Division of Infectious Diseases Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Department of Internal Medicine Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Radboud Center for Infectious Diseases Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai G.","family":"Netea","sequence":"additional","affiliation":[{"name":"Radboud Expertise Center for Q fever Department of Internal Medicine Division of Infectious Diseases Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Department of Internal Medicine Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Radboud Center for Infectious Diseases Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal P.","family":"Bleeker\u2010Rovers","sequence":"additional","affiliation":[{"name":"Radboud Expertise Center for Q fever Department of Internal Medicine Division of Infectious Diseases Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Department of Internal Medicine Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Radboud Center for Infectious Diseases Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68266-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00045-16"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268812001203"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00175-11"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002056"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91470-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155884"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/91.8.549"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.01.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.04.006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.06.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.034"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12647"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.011"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12162-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028680"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2017.03.003"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.10.6441-6448.2005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000115"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65068-7"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250684"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251086"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.034"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05836"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.10.008"},{"key":"e_1_2_8_28_1","first-page":"57","volume-title":"Multidisciplinaire 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