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In fact, oral administration of lipoteichoic acid (LTA) from\n                    <jats:italic>Lactobacillus rhamnosus<\/jats:italic>\n                    GG (LGG) prevents the development of UV\u2010induced skin tumors in chronically exposed mice. Here we aim to evaluate whether this LTA is able to revert UV\u2010induced immunosuppression as a mechanism involved in its anti\u2010tumor effect and whether it has an immunotherapeutic effect against cutaneous squamous cell carcinoma. Using a mouse model of contact hypersensitivity, we demonstrate that LTA overcomes UV\u2010induced skin immunosuppression. This effect was in part achieved by modulating the phenotype of lymph node resident dendritic cells (DC) and the homing of skin migratory DC. Importantly, oral LTA reduced significantly the growth of established skin tumors once UV radiation was discontinued, demonstrating that it has a therapeutic, besides the already demonstrated preventive antitumor effect. The data presented here strongly indicates that oral administration of LTA represents a promising immunotherapeutic approach for different conditions in which the skin immune system is compromised.\n                  <\/jats:p>","DOI":"10.1002\/eji.201848024","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T11:10:54Z","timestamp":1563880254000},"page":"2095-2102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Oral administration of lipoteichoic acid from\n                    <i>Lactobacillus rhamnosus<\/i>\n                    GG overcomes UVB\u2010induced immunosuppression and impairs skin tumor growth in mice"],"prefix":"10.1002","volume":"49","author":[{"given":"Adri\u00e1n D.","family":"Friedrich","sequence":"first","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Inmunolog\u00eda  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria E.","family":"Campo","sequence":"additional","affiliation":[{"name":"CONICET \u2013 Universidad de Buenos Aires, Instituto de Estudios de la Inmunidad Humoral (IDEHU)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana M.","family":"Cela","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Inmunolog\u00eda  Buenos Aires Argentina"},{"name":"CONICET \u2013 Universidad de Buenos Aires, Instituto de Estudios de la Inmunidad Humoral (IDEHU)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian E.","family":"Morelli","sequence":"additional","affiliation":[{"name":"Department of Surgery and Thomas E. 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Starzl Transplantation Institute University of Pittsburgh, School of Medicine  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A.","family":"Tckacheva","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pittsburgh School of Medicine  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Leoni","sequence":"additional","affiliation":[{"name":"CONICET \u2013 Universidad de Buenos Aires, Instituto de Estudios de la Inmunidad Humoral (IDEHU)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela L.","family":"Paz","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Inmunolog\u00eda  Buenos Aires Argentina"},{"name":"CONICET \u2013 Universidad de Buenos Aires, Instituto de Estudios de la Inmunidad Humoral (IDEHU)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana T.","family":"Larregina","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pittsburgh School of Medicine  Pittsburgh PA USA"},{"name":"Department of Immunology University of Pittsburgh School of Medicine Pittsburgh  PA USA"},{"name":"The McGowan Institute for Regenerative Medicine University of Pittsburgh School of Medicine  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3150-7475","authenticated-orcid":false,"given":"Daniel H.","family":"Gonz\u00e1lez Maglio","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Inmunolog\u00eda  Buenos Aires Argentina"},{"name":"CONICET \u2013 Universidad de Buenos Aires, Instituto de Estudios de la Inmunidad Humoral (IDEHU)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061067"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0506312"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.10.014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2553"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127262"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.10.2.259-266.2003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.4.1688"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/53.5.1333"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/57.1.211"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23615.x"},{"key":"e_1_2_7_12_1","first-page":"79","article-title":"Role of tumour necrosis factor\u2010alpha in ultraviolet B light\u2010induced dendritic cell migration and suppression of contact hypersensitivity","volume":"81","author":"Moodycliffe A. 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