{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T21:06:07Z","timestamp":1784667967681,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006315","name":"ReumaNederland","doi-asserted-by":"publisher","award":["13\u20103\u2010403"],"award-info":[{"award-number":["13\u20103\u2010403"]}],"id":[{"id":"10.13039\/501100006315","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    IL\u201023 plays an important role in the development of arthritis and the IL\u201023 receptor (IL\u201023R) is expressed on different types of T\u00a0cells. However, it is not fully clear which IL\u201023R\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells are critical in driving T\u00a0cell\u2010mediated synovitis. We demonstrate, using knock\u2010in IL\u201023R\u2010GFP reporter (IL\u201023R\n                    <jats:sup>GFP\/+<\/jats:sup>\n                    ) mice, that CD4\n                    <jats:sup>+<\/jats:sup>\n                    CCR6\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells and \u03b3\u03b4 T\u00a0cells, but not CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells, express the IL\u201023R(GFP). During early arthritis, IL\u201023R(GFP)\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    CCR6\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells, but not IL\u201023R(GFP)\n                    <jats:sup>+<\/jats:sup>\n                    \u03b3\u03b4 T\u00a0cells, were present in the inflamed joints. IL\u201023R\n                    <jats:sup>GFP\/+<\/jats:sup>\n                    mice were bred as homozygotes to obtain IL\u201023R\n                    <jats:sup>GFP\/GFP<\/jats:sup>\n                    (IL\u201023R deficient\/IL\u201023R\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice, which express GFP under the IL\u201023R promotor. Arthritis progression and joint damage were significantly milder in IL\u201023R\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, which revealed less IL\u201017A\n                    <jats:sup>+<\/jats:sup>\n                    cells in their lymphoid tissues. Surprisingly, IL\u201023R\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice had increased numbers of IL\u201023R(GFP)\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    CCR6\n                    <jats:sup>+<\/jats:sup>\n                    and CCR7\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    CCR6\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells in their spleen compared to WT, and IL\u201023 suppressed CCR7 expression in vitro. However, IL\u201023R(GFP)\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    CCR6\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells were present in the synovium of IL\u201023R\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice at day 4. Finally, adoptive transfer experiments revealed that CD4\n                    <jats:sup>+<\/jats:sup>\n                    CCR6\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells and not \u03b3\u03b4 T\u00a0cells drive arthritis progression. These data suggest that IL\u201023R\u2010dependent T\u00a0cell\u2010mediated synovitis is dependent on CD4\n                    <jats:sup>+<\/jats:sup>\n                    CCR6\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells and not on \u03b3\u03b4 T\u00a0cells.\n                  <\/jats:p>","DOI":"10.1002\/eji.201948112","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T22:43:49Z","timestamp":1573598629000},"page":"245-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["CD4\n                    <sup>+<\/sup>\n                    CCR6\n                    <sup>+<\/sup>\n                    T\u00a0cells, but not \u03b3\u03b4 T\u00a0cells, are important for the IL\u201023R\u2010dependent progression of antigen\u2010induced inflammatory arthritis in mice"],"prefix":"10.1002","volume":"50","author":[{"given":"Wida","family":"Razawy","sequence":"first","affiliation":[{"name":"Department of Rheumatology Erasmus MC University Medical Center  Rotterdam The Netherlands"},{"name":"Department of Immunology University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.","family":"Asmawidjaja","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Erasmus MC University Medical Center  Rotterdam The Netherlands"},{"name":"Department of Immunology University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Mus","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Erasmus MC University Medical Center  Rotterdam The Netherlands"},{"name":"Department of Immunology University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazike","family":"Salioska","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Erasmus MC University Medical Center  Rotterdam The Netherlands"},{"name":"Department of Immunology University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Davelaar","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Erasmus MC University Medical Center  Rotterdam The Netherlands"},{"name":"Department of Immunology University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Kops","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Oukka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seattle Children's Research Institute Center for Immunity and Immunotherapies  Seattle USA"},{"name":"Department of Immunology University of Washington  Seattle USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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