{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:11:44Z","timestamp":1782321104237,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","award":["SBF002\/1076"],"award-info":[{"award-number":["SBF002\/1076"]}],"id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Helminth infections are a global health burden in humans and livestock and are considered to be a major evolutionary driver of type 2 immunity (orchestrated by type 2 cytokines, e.g., IL\u20104 and IL\u201013). Upon infection, helminths cause substantial damage to mucosal tissues as they migrate within the host and elicit crucial protective immune mechanisms. Macrophages, essential innate cells, are known to adopt a specific activation status (termed M(IL\u20104)) in type 2 cytokine environments. Yet, the role of these macrophages in mediating protective immune\/wound healing responses to helminths is unclear. Furthermore, macrophage subsets can be very heterogenous (linked to their differing cellular origins) and the relative role of these subsets in the context of M(IL\u20104) activation to helminth infection is unknown. An article by Rolot <jats:italic>et\u00a0al<\/jats:italic>. in this issue of the <jats:italic>European Journal of Immunology<\/jats:italic> [Eur. J. Immunol. 2019. 49: 1067\u20131081] uses a variety of transgenic murine strains to revise our understanding of the complexity of how these subsets undergo M(IL\u20104) activation and participate in wound healing responses in helminth infection. Here we highlight that consideration of different macrophage subsets in mucosal tissues is essential when evaluating the functional role of M(IL\u20104) macrophages.<\/jats:p>","DOI":"10.1002\/eji.201948158","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T07:03:15Z","timestamp":1562137395000},"page":"996-1000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Macrophages assemble! But do they need IL\u20104R during schistosomiasis?"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0206-1451","authenticated-orcid":false,"given":"Dominik","family":"R\u00fcckerl","sequence":"first","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation Faculty of Biology Medicine and Health University of Manchester Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5208-4985","authenticated-orcid":false,"given":"Peter C.","family":"Cook","sequence":"additional","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation Manchester Collaborative Centre for Inflammation Research Faculty of Biology Medicine and\u00a0Health University of Manchester Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.10.016"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12221"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002003"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121999"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204351"},{"key":"e_1_2_4_7_1","first-page":"2253","article-title":"Recruitment of hepatic macrophages from monocytes is independent of IL\u20104R\u03b1 but is associated with ablation of resident macrophages in schistosomiasis","volume":"383","author":"Rolot M.","year":"2019","journal-title":"Eur. 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