{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:04:20Z","timestamp":1782144260944,"version":"3.54.5"},"reference-count":57,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/8\/5\/26\/2011\u2010ECD"],"award-info":[{"award-number":["5\/8\/5\/26\/2011\u2010ECD"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["3\/1\/3\/JRF\u20102009\/MPD\u2010103"],"award-info":[{"award-number":["3\/1\/3\/JRF\u20102009\/MPD\u2010103"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Aging influences the susceptibility and prognosis to various infectious diseases including tuberculosis (TB). Despite the impairment of T\u2010cell function and immunity in older individuals, the mechanism for the higher incidence of TB in the elderly remains largely unknown. Here, we evaluated the age\u2010associated immune alterations, particularly in effector and Treg responses in pulmonary TB patients. We also evaluated the impact of redox status and its modulation with\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl\u2010cysteine (NAC) in elderly TB. Higher frequency of Treg cells and reduced IFN\u2010\u03b3 positive T cells were observed among older TB patients. The elevated number of Treg cells correlated tightly with bacillary load (i.e. disease severity); which declined significantly in response to successful anti\u2010tubercular treatment. We could rescue\n                    <jats:italic>Myobacterium tuberculosis<\/jats:italic>\n                    \u2010specific effector T cell (Th1) responses through various in vitro approaches, for example, Treg cell depletion and co\u2010culture experiments, blocking experiments using antibodies against IL\u201010, TGF\u2010\u03b2, and programmed death\u20101 (PD\u20101) as well as NAC supplementation. We report old age\u2010associated enrichment of Treg cells and suppression of\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    \u2010specific effector T (Th1) cell immune responses. Monitoring these immune imbalances in older patients may assist in immune potentiation through selectively targeting Treg cells and\/or optimizing redox status by NAC supplementation.\n                  <\/jats:p>","DOI":"10.1002\/eji.201948261","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T15:05:03Z","timestamp":1588604703000},"page":"1195-1208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Old age\u2010associated enrichment of peripheral T regulatory cells and altered redox status in pulmonary tuberculosis patients"],"prefix":"10.1002","volume":"50","author":[{"given":"Manju","family":"Namdeo","sequence":"first","affiliation":[{"name":"Department of Transplant Immunology and Immunogenetics All India Institute of Medical Sciences  New Delhi 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