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Amy1\u2010LT\u03b1\u03b2 mice developed atrophic salivary and lacrimal glands that contained tertiary lymphoid organs (TLOs) and had reduced tear production. Amy1\u2010LT\u03b1\u03b2 mice developed cervical lymphadenopathy but not MALT\u2010lymphoma. TLO formation in the salivary and lacrimal glands of Amy1\u2010LT\u03b1\u03b2 was not sufficient to induce autoimmunity as measured by autoantibody titres.<\/jats:p>","DOI":"10.1002\/eji.201948300","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T15:46:57Z","timestamp":1580744817000},"page":"418-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lymphotoxin targeted to salivary and lacrimal glands induces tertiary lymphoid organs and cervical lymphadenopathy and reduces tear production"],"prefix":"10.1002","volume":"50","author":[{"given":"Lucy A.","family":"Truman","sequence":"first","affiliation":[{"name":"ENT Department West Suffolk Hospital, Hardwick Lane  Bury St Edmunds UK"},{"name":"Yale School of Public Health  New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L.","family":"Bentley","sequence":"additional","affiliation":[{"name":"Yale School of Public Health  New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0103-1461","authenticated-orcid":false,"given":"Nancy H.","family":"Ruddle","sequence":"additional","affiliation":[{"name":"Yale School of Public Health  New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.11.6749-6754.2001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300872"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-186973"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1330"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8171322"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80292-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.4.1461"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201216"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.07.112"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1948.tb10081.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.04.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200446"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp383"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3507"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001520"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-321265"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05712.x"},{"key":"e_1_2_8_19_1","first-page":"367","article-title":"Tear production rate in a mouse model of dry eye according to the phenol red thread and endodontic absorbent paper point tear tests","volume":"66","author":"Kilic S.","year":"2016","journal-title":"Comp. 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