{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:12:38Z","timestamp":1780467158291,"version":"3.54.1"},"reference-count":65,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T00:00:00Z","timestamp":1584576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    SOCS3 is a cytosolic inhibitor of cytokine signaling that suppresses the activation of cytokine receptor\u2010associated JAK kinases. Mechanistically, SOCS3 is recruited to a site in the cytokine receptors known as the SOCS3\u2010interaction motif, and then binds JAK molecules to inhibit their kinase activity. The SOCS3\u2010interaction motif is found in receptors of the gp130 cytokine family but mostly absent from other cytokine receptors, including \u03b3c. Thus, SOCS3 has been considered a selective suppressor of gp130 family cytokines, but not \u03b3c cytokines. Considering that \u03b3c signaling induces SOCS3 expression in T cells, here we revisited the role of SOCS3 on \u03b3c signaling. Using SOCS3 transgenic mice, we found that increased abundance of SOCS3 not only suppressed signaling of the gp130 family cytokine IL\u20106, but also signaling of the \u03b3c family cytokine IL\u20107. Consequently, SOCS3 transgenic mice were impaired in IL\u20107\u2010dependent T cell development in the thymus and the homeostasis of mature T cells in peripheral tissues. Moreover, enforced SOCS3 expression interfered with the generation of Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T cells that requires signaling by the \u03b3c family cytokine IL\u20102. Collectively, we report an underappreciated role for SOCS3 in suppressing \u03b3c cytokine signaling, effectively expanding its scope of target cytokines in T cell immunity.\n                  <\/jats:p>","DOI":"10.1002\/eji.201948307","type":"journal-article","created":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T00:53:56Z","timestamp":1583542436000},"page":"986-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["SOCS3 is a suppressor of \u03b3c cytokine signaling and constrains generation of murine Foxp3\n                    <sup>+<\/sup>\n                    regulatory T cells"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9674-0753","authenticated-orcid":false,"given":"Megan A.","family":"Luckey","sequence":"first","affiliation":[{"name":"Experimental Immunology Branch, Center for Cancer Research National Cancer Institute, NIH  Bethesda 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