{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:15:17Z","timestamp":1781115317778,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Extracorporeal photochemotherapy (ECP) that takes advantage of the immunomodulatory effects of UV light has been extensively used for many years for the treatment of several T cell\u2013mediated diseases, including graft\u2010versus\u2010host disease (GvHD) and systemic scleroderma. Immune mechanisms that lead to the establishment of T cell tolerance in ECP\u2010treated patients remain poorly known. In this study, we have tested the effect of UV\/psoralen\u2010treated BM\u2010derived dendritic cells, referred to as ECP\u2010BMDCs on the outcome of an antigen\u2010specific T cell\u2010mediated reaction, that is, contact hypersensitivity (CHS), which is mediated by CD8\n                    <jats:sup>+<\/jats:sup>\n                    effector T cells (CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>eff<\/jats:sub>\n                    ). The intravenous (i.v.) injection of antigen\u2010pulsed ECP\u2010BMDCs in recipient C57BL\/6 mice induced specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells endowed with immunomodulatory properties (referred to as CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>ECP<\/jats:sub>\n                    ), which prevented the priming of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>eff<\/jats:sub>\n                    and the development of CHS, independently of conventional CD4\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T cells. CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>ECP<\/jats:sub>\n                    mediated tolerance by inhibiting the migration and functions of skin DC and subsequently the priming of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>eff<\/jats:sub>\n                    . CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>ECP<\/jats:sub>\n                    displayed none of the phenotypes of the usual CD8\n                    <jats:sup>+<\/jats:sup>\n                    T regulatory cells described so far. Our results reveal an underestimated participation of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells to ECP\u2010induced immunomodulation that could explain the therapeutic effects of ECP in T cell\u2010mediated diseases.\n                  <\/jats:p>","DOI":"10.1002\/eji.201948318","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T16:11:37Z","timestamp":1580746297000},"page":"725-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["CD8\n                    <sup>+<\/sup>\n                    T cells mediate ultraviolet A\u2010induced immunomodulation in a model of extracorporeal photochemotherapy"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5650-5786","authenticated-orcid":false,"given":"Olivier","family":"Hequet","sequence":"first","affiliation":[{"name":"CIRI \u2013 Centre International de Recherche en Infectiologie Team \u00ab\u00a0Immunology of Skin Allergy and Vaccination\u00a0\u00bb Inserm, U1111 Universit\u00e9 Claude Bernard Lyon 1 CNRS, UMR5308 Ecole Normale Sup\u00e9rieure de Lyon Lyon University  F\u201069007 Lyon France"},{"name":"Etablissement Fran\u00e7ais du Sang (EFS) Auvergne Rh\u00f4ne\u2010Alpes Apheresis Unit H\u00f4pital Lyon Sud  Pierre B\u00e9nite France"},{"name":"Etablissement Fran\u00e7ais du Sang (EFS) Auvergne Rh\u00f4ne\u2010Alpes Scientific Departements  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Nosbaum","sequence":"additional","affiliation":[{"name":"CIRI \u2013 Centre International de Recherche en Infectiologie Team \u00ab\u00a0Immunology of Skin Allergy and Vaccination\u00a0\u00bb Inserm, U1111 Universit\u00e9 Claude Bernard Lyon 1 CNRS, UMR5308 Ecole Normale Sup\u00e9rieure de Lyon Lyon University  F\u201069007 Lyon 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