{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:22:46Z","timestamp":1785298966373,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010307","name":"Dr. F.P. Fischer-Stichting","doi-asserted-by":"publisher","award":["FS2016\u20101"],"award-info":[{"award-number":["FS2016\u20101"]}],"id":[{"id":"10.13039\/501100010307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010372","name":"Rotterdamse Stichting Blindenbelangen","doi-asserted-by":"publisher","award":["\"Een nieuwe bloedtest voor het detecteren van oogk"],"award-info":[{"award-number":["\"Een nieuwe bloedtest voor het detecteren van oogk"]}],"id":[{"id":"10.13039\/501100010372","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010328","name":"Stichting Lijf en Leven","doi-asserted-by":"publisher","award":["\u201cEen nieuwe bloedtest voor het detecteren van oo"],"award-info":[{"award-number":["\u201cEen nieuwe bloedtest voor het detecteren van oo"]}],"id":[{"id":"10.13039\/501100010328","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Non\u2010Hodgkin orbital lymphoma (NHOL) and idiopathic orbital inflammation (IOI) are common orbital conditions with largely unknown pathophysiology that can be difficult to diagnose. In this study we aim to identify serum miRNAs associated with NHOL and IOI. We performed\n                    <jats:italic>OpenArray<\/jats:italic>\n                    <jats:sup>\u00ae<\/jats:sup>\n                    miRNA profiling in 33 patients and controls. Differentially expressed miRNAs were technically validated across technology platforms and replicated in an additional cohort of 32 patients and controls. We identified and independently validated a serum miRNA profile of NHOL that was remarkably similar to IOI and characterized by an increased expression of a cluster of eight miRNAs. Pathway enrichment analysis indicated that the miRNA\u2010cluster is associated with immune\u2010mediated pathways, which we supported by demonstrating the elevated expression of this cluster in serum of patients with other inflammatory conditions. The cluster contained\n                    <jats:italic>miR\u2010148a<\/jats:italic>\n                    , a key driver of B\u2010cell tolerance, and\n                    <jats:italic>miR\u2010365<\/jats:italic>\n                    that correlated with serum IgG and IgM concentrations. In addition,\n                    <jats:italic>miR\u201029a<\/jats:italic>\n                    and\n                    <jats:italic>miR\u2010223<\/jats:italic>\n                    were associated with blood lymphocyte and neutrophil populations, respectively. NHOL and IOI are characterized by an abnormal serum miRNA\u2010cluster associated with immune pathway activation and linked to B cell and neutrophil dysfunction.\n                  <\/jats:p>","DOI":"10.1002\/eji.201948343","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T04:57:08Z","timestamp":1573534628000},"page":"86-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A pan\u2010inflammatory microRNA\u2010cluster is associated with orbital non\u2010Hodgkin lymphoma and idiopathic orbital inflammation"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8817-371X","authenticated-orcid":false,"given":"Kamil G.","family":"Laban","sequence":"first","affiliation":[{"name":"Ophthalmo\u2010Immunology Unit University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"},{"name":"Department of Ophthalmology University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"},{"name":"Laboratory of Translational Immunology University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Kalmann","sequence":"additional","affiliation":[{"name":"Ophthalmo\u2010Immunology Unit University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"},{"name":"Department of Ophthalmology University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis P. J.","family":"Bekker","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Immunology University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"},{"name":"Department of Rheumatology &amp; Clinical Immunology University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne","family":"Hiddingh","sequence":"additional","affiliation":[{"name":"Ophthalmo\u2010Immunology Unit University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"},{"name":"Department of Ophthalmology University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"},{"name":"Laboratory of Translational Immunology University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob L. P.","family":"van der Veen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A. E.","family":"Eenhorst","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn W.","family":"Genders","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten P.","family":"Mourits","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8793-4954","authenticated-orcid":false,"given":"Fleurieke H.","family":"Verhagen","sequence":"additional","affiliation":[{"name":"Ophthalmo\u2010Immunology Unit University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"},{"name":"Department of Ophthalmology University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"},{"name":"Laboratory of Translational Immunology University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmerik F. A.","family":"Leijten","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Immunology University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"},{"name":"Department of Rheumatology &amp; Clinical Immunology University Medical Center Utrecht University Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Haitjema","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Chemistry and Haematology University Medical Center Utrecht Utrecht University  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C. H.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Chemistry and Haematology University Medical Center Utrecht Utrecht University  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R. D. 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